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Structural and Functional Characterization of the Human Protein Kinase ASK1

Apoptosis signal-regulating kinase 1 (ASK1) plays an essential role in stress and immune response and has been linked to the development of several diseases. Here, we present the structure of the human ASK1 catalytic domain in complex with staurosporine. Analytical ultracentrifugation (AUC) and crys...

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Detalles Bibliográficos
Autores principales:	Bunkoczi, Gabor, Salah, Eidarus, Filippakopoulos, Panagis, Fedorov, Oleg, Müller, Susanne, Sobott, Frank, Parker, Sirlester A., Zhang, Haifeng, Min, Wang, Turk, Benjamin E., Knapp, Stefan
Formato:	Texto
Lenguaje:	English
Publicado:	Cell Press 2007
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2100151/ https://www.ncbi.nlm.nih.gov/pubmed/17937911 http://dx.doi.org/10.1016/j.str.2007.08.011

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