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Measuring the Burden of Neglected Tropical Diseases: The Global Burden of Disease Framework

Reliable, comparable information about the main causes of disease and injury in populations, and how these are changing, is a critical input for debates about priorities in the health sector. Traditional sources of information about the descriptive epidemiology of diseases, injuries, and risk factor...

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Autores principales: Mathers, Colin D., Ezzati, Majid, Lopez, Alan D.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2100367/
https://www.ncbi.nlm.nih.gov/pubmed/18060077
http://dx.doi.org/10.1371/journal.pntd.0000114
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author Mathers, Colin D.
Ezzati, Majid
Lopez, Alan D.
author_facet Mathers, Colin D.
Ezzati, Majid
Lopez, Alan D.
author_sort Mathers, Colin D.
collection PubMed
description Reliable, comparable information about the main causes of disease and injury in populations, and how these are changing, is a critical input for debates about priorities in the health sector. Traditional sources of information about the descriptive epidemiology of diseases, injuries, and risk factors are generally incomplete, fragmented, and of uncertain reliability and comparability. The Global Burden of Disease (GBD) study has provided a conceptual and methodological framework to quantify and compare the health of populations using a summary measure of both mortality and disability, the disability-adjusted life year (DALY). This paper describes key features of the Global Burden of Disease analytic approach, which provides a standardized measurement framework to permit comparisons across diseases and injuries, as well as risk factors, and a systematic approach to the evaluation of data. The paper describes the evolution of the GBD, starting from the first study for the year 1990, summarizes the methodological improvements incorporated into GBD revisions for the years 2000–2004 carried out by the World Health Organization, and examines priorities and issues for the next major GBD study, funded by the Bill & Melinda Gates Foundation, and commencing in 2007. The paper presents an overview of summary results from the Global Burden of Disease study 2002, with a particular focus on the neglected tropical diseases, and also an overview of the comparative risk assessment for 26 global risk factors. Taken together, trypanosomiasis, Chagas disease, schistosomiasis, leishmaniasis, lymphatic filariasis, onchocerciasis, intestinal nematode infections, Japanese encephalitis, dengue, and leprosy accounted for an estimated 177,000 deaths worldwide in 2002, mostly in sub-Saharan Africa, and about 20 million DALYs, or 1.3% of the global burden of disease and injuries. Further research is currently underway to revise and update these estimates.
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spelling pubmed-21003672007-12-05 Measuring the Burden of Neglected Tropical Diseases: The Global Burden of Disease Framework Mathers, Colin D. Ezzati, Majid Lopez, Alan D. PLoS Negl Trop Dis Review Reliable, comparable information about the main causes of disease and injury in populations, and how these are changing, is a critical input for debates about priorities in the health sector. Traditional sources of information about the descriptive epidemiology of diseases, injuries, and risk factors are generally incomplete, fragmented, and of uncertain reliability and comparability. The Global Burden of Disease (GBD) study has provided a conceptual and methodological framework to quantify and compare the health of populations using a summary measure of both mortality and disability, the disability-adjusted life year (DALY). This paper describes key features of the Global Burden of Disease analytic approach, which provides a standardized measurement framework to permit comparisons across diseases and injuries, as well as risk factors, and a systematic approach to the evaluation of data. The paper describes the evolution of the GBD, starting from the first study for the year 1990, summarizes the methodological improvements incorporated into GBD revisions for the years 2000–2004 carried out by the World Health Organization, and examines priorities and issues for the next major GBD study, funded by the Bill & Melinda Gates Foundation, and commencing in 2007. The paper presents an overview of summary results from the Global Burden of Disease study 2002, with a particular focus on the neglected tropical diseases, and also an overview of the comparative risk assessment for 26 global risk factors. Taken together, trypanosomiasis, Chagas disease, schistosomiasis, leishmaniasis, lymphatic filariasis, onchocerciasis, intestinal nematode infections, Japanese encephalitis, dengue, and leprosy accounted for an estimated 177,000 deaths worldwide in 2002, mostly in sub-Saharan Africa, and about 20 million DALYs, or 1.3% of the global burden of disease and injuries. Further research is currently underway to revise and update these estimates. Public Library of Science 2007-11-07 /pmc/articles/PMC2100367/ /pubmed/18060077 http://dx.doi.org/10.1371/journal.pntd.0000114 Text en Mathers et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Review
Mathers, Colin D.
Ezzati, Majid
Lopez, Alan D.
Measuring the Burden of Neglected Tropical Diseases: The Global Burden of Disease Framework
title Measuring the Burden of Neglected Tropical Diseases: The Global Burden of Disease Framework
title_full Measuring the Burden of Neglected Tropical Diseases: The Global Burden of Disease Framework
title_fullStr Measuring the Burden of Neglected Tropical Diseases: The Global Burden of Disease Framework
title_full_unstemmed Measuring the Burden of Neglected Tropical Diseases: The Global Burden of Disease Framework
title_short Measuring the Burden of Neglected Tropical Diseases: The Global Burden of Disease Framework
title_sort measuring the burden of neglected tropical diseases: the global burden of disease framework
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2100367/
https://www.ncbi.nlm.nih.gov/pubmed/18060077
http://dx.doi.org/10.1371/journal.pntd.0000114
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