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Crystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ

The recently characterised 299-residue human XLF/Cernunnos protein plays a crucial role in DNA repair by non-homologous end joining (NHEJ) and interacts with the XRCC4–DNA Ligase IV complex. Here, we report the crystal structure of the XLF (1–233) homodimer at 2.3 Å resolution, confirming the predic...

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Detalles Bibliográficos
Autores principales:	Li, Yi, Chirgadze, Dimitri Y, Bolanos-Garcia, Victor M, Sibanda, Bancinyane L, Davies, Owen R, Ahnesorg, Peter, Jackson, Stephen P, Blundell, Tom L
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2008
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2104711/ https://www.ncbi.nlm.nih.gov/pubmed/18046455 http://dx.doi.org/10.1038/sj.emboj.7601942

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