INVERSE ENZYMATIC CHANGES IN NEURONS AND GLIA DURING INCREASED FUNCTION AND HYPOXIA

Following stimulation of the vestibular nerve in the rabbit, respiratory enzyme activities increased in Deiters' nerve cells. The anaerobic glycolysis, measured as 10(-4) µl CO(2) per hour per cell, was found to decrease concomitantly by 25 to 40 per cent, suggesting a Pasteur effect. By contra...

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Detalles Bibliográficos
Autores principales: Hamberger, Anders, Hydén, Holger
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1963
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2106232/
https://www.ncbi.nlm.nih.gov/pubmed/13952284
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author Hamberger, Anders
Hydén, Holger
author_facet Hamberger, Anders
Hydén, Holger
author_sort Hamberger, Anders
collection PubMed
description Following stimulation of the vestibular nerve in the rabbit, respiratory enzyme activities increased in Deiters' nerve cells. The anaerobic glycolysis, measured as 10(-4) µl CO(2) per hour per cell, was found to decrease concomitantly by 25 to 40 per cent, suggesting a Pasteur effect. By contrast, in the surrounding glia the anaerobic glycolysis increased and the respiratory enzyme activity decreased, suggesting a Crabtree effect. The evidence is discussed for a regulatory metabolic mechanism operating between the neuron and its glia. Hypoxia of 8 per cent O(2) caused an increase of both oxygen consumption and CO(2) production in the nerve cells, but did not change the glia values.
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spelling pubmed-21062322008-05-01 INVERSE ENZYMATIC CHANGES IN NEURONS AND GLIA DURING INCREASED FUNCTION AND HYPOXIA Hamberger, Anders Hydén, Holger J Cell Biol Article Following stimulation of the vestibular nerve in the rabbit, respiratory enzyme activities increased in Deiters' nerve cells. The anaerobic glycolysis, measured as 10(-4) µl CO(2) per hour per cell, was found to decrease concomitantly by 25 to 40 per cent, suggesting a Pasteur effect. By contrast, in the surrounding glia the anaerobic glycolysis increased and the respiratory enzyme activity decreased, suggesting a Crabtree effect. The evidence is discussed for a regulatory metabolic mechanism operating between the neuron and its glia. Hypoxia of 8 per cent O(2) caused an increase of both oxygen consumption and CO(2) production in the nerve cells, but did not change the glia values. The Rockefeller University Press 1963-03-01 /pmc/articles/PMC2106232/ /pubmed/13952284 Text en Copyright © Copyright, 1963, by The Rockefeller Institute Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Hamberger, Anders
Hydén, Holger
INVERSE ENZYMATIC CHANGES IN NEURONS AND GLIA DURING INCREASED FUNCTION AND HYPOXIA
title INVERSE ENZYMATIC CHANGES IN NEURONS AND GLIA DURING INCREASED FUNCTION AND HYPOXIA
title_full INVERSE ENZYMATIC CHANGES IN NEURONS AND GLIA DURING INCREASED FUNCTION AND HYPOXIA
title_fullStr INVERSE ENZYMATIC CHANGES IN NEURONS AND GLIA DURING INCREASED FUNCTION AND HYPOXIA
title_full_unstemmed INVERSE ENZYMATIC CHANGES IN NEURONS AND GLIA DURING INCREASED FUNCTION AND HYPOXIA
title_short INVERSE ENZYMATIC CHANGES IN NEURONS AND GLIA DURING INCREASED FUNCTION AND HYPOXIA
title_sort inverse enzymatic changes in neurons and glia during increased function and hypoxia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2106232/
https://www.ncbi.nlm.nih.gov/pubmed/13952284
work_keys_str_mv AT hambergeranders inverseenzymaticchangesinneuronsandgliaduringincreasedfunctionandhypoxia
AT hydenholger inverseenzymaticchangesinneuronsandgliaduringincreasedfunctionandhypoxia

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