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Wrenches in the works: drug discovery targeting the SCF ubiquitin ligase and APC/C complexes
Recently, the ubiquitin proteasome system (UPS) has matured as a drug discovery arena, largely on the strength of the proven clinical activity of the proteasome inhibitor Velcade in multiple myeloma. Ubiquitin ligases tag cellular proteins, such as oncogenes and tumor suppressors, with ubiquitin. On...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2007
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2106342/ https://www.ncbi.nlm.nih.gov/pubmed/18047746 http://dx.doi.org/10.1186/1471-2091-8-S1-S9 |