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THE RELATIONS BETWEEN DNA, RNA, AND PROTEIN IN NORMAL EMBRYONIC CELL NUCLEI AND SPONTANEOUS TUMOUR CELL NUCLEI
Interferometric and photometric measurements have been made successively on individual cell nuclei derived from normal embryonic tissues and spontaneous tumour tissues of the mouse grown in vivo. From the measurements, the relations between nucleic acid and dry mass content have been studied in the...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1964
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2106345/ https://www.ncbi.nlm.nih.gov/pubmed/14105209 |
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author | Seed, John |
author_facet | Seed, John |
author_sort | Seed, John |
collection | PubMed |
description | Interferometric and photometric measurements have been made successively on individual cell nuclei derived from normal embryonic tissues and spontaneous tumour tissues of the mouse grown in vivo. From the measurements, the relations between nucleic acid and dry mass content have been studied in the two types of nuclei and the results shown to be consistent with differences in cell metabolism previously reported to exist in vitro. In the nuclei of normal embryonic cells, the syntheses of DNA, nuclear RNA, and protein appear to be closely associated, whereas in the tumour cell nuclei an appreciable fraction of the chromatin RNA and protein synthesis is dissociated from the replication of DNA. |
format | Text |
id | pubmed-2106345 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1964 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21063452008-05-01 THE RELATIONS BETWEEN DNA, RNA, AND PROTEIN IN NORMAL EMBRYONIC CELL NUCLEI AND SPONTANEOUS TUMOUR CELL NUCLEI Seed, John J Cell Biol Article Interferometric and photometric measurements have been made successively on individual cell nuclei derived from normal embryonic tissues and spontaneous tumour tissues of the mouse grown in vivo. From the measurements, the relations between nucleic acid and dry mass content have been studied in the two types of nuclei and the results shown to be consistent with differences in cell metabolism previously reported to exist in vitro. In the nuclei of normal embryonic cells, the syntheses of DNA, nuclear RNA, and protein appear to be closely associated, whereas in the tumour cell nuclei an appreciable fraction of the chromatin RNA and protein synthesis is dissociated from the replication of DNA. The Rockefeller University Press 1964-01-01 /pmc/articles/PMC2106345/ /pubmed/14105209 Text en Copyright © 1964 by The Rockefeller Institute Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Seed, John THE RELATIONS BETWEEN DNA, RNA, AND PROTEIN IN NORMAL EMBRYONIC CELL NUCLEI AND SPONTANEOUS TUMOUR CELL NUCLEI |
title | THE RELATIONS BETWEEN DNA, RNA, AND PROTEIN IN NORMAL EMBRYONIC CELL NUCLEI AND SPONTANEOUS TUMOUR CELL NUCLEI |
title_full | THE RELATIONS BETWEEN DNA, RNA, AND PROTEIN IN NORMAL EMBRYONIC CELL NUCLEI AND SPONTANEOUS TUMOUR CELL NUCLEI |
title_fullStr | THE RELATIONS BETWEEN DNA, RNA, AND PROTEIN IN NORMAL EMBRYONIC CELL NUCLEI AND SPONTANEOUS TUMOUR CELL NUCLEI |
title_full_unstemmed | THE RELATIONS BETWEEN DNA, RNA, AND PROTEIN IN NORMAL EMBRYONIC CELL NUCLEI AND SPONTANEOUS TUMOUR CELL NUCLEI |
title_short | THE RELATIONS BETWEEN DNA, RNA, AND PROTEIN IN NORMAL EMBRYONIC CELL NUCLEI AND SPONTANEOUS TUMOUR CELL NUCLEI |
title_sort | relations between dna, rna, and protein in normal embryonic cell nuclei and spontaneous tumour cell nuclei |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2106345/ https://www.ncbi.nlm.nih.gov/pubmed/14105209 |
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