Role of the ubiquitin system and tumor viruses in AIDS-related cancer

Tumor viruses are linked to approximately 20% of human malignancies worldwide. This review focuses on examples of human oncogenic viruses that manipulate the ubiquitin system in a subset of viral malignancies; those associated with AIDS. The viruses include Kaposi's sarcoma herpesvirus, Epstein...

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Detalles Bibliográficos
Autores principales: Shackelford, Julia, Pagano, Joseph S
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2106372/
https://www.ncbi.nlm.nih.gov/pubmed/18047745
http://dx.doi.org/10.1186/1471-2091-8-S1-S8
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author Shackelford, Julia
Pagano, Joseph S
author_facet Shackelford, Julia
Pagano, Joseph S
author_sort Shackelford, Julia
collection PubMed
description Tumor viruses are linked to approximately 20% of human malignancies worldwide. This review focuses on examples of human oncogenic viruses that manipulate the ubiquitin system in a subset of viral malignancies; those associated with AIDS. The viruses include Kaposi's sarcoma herpesvirus, Epstein-Barr virus and human papilloma virus, which are causally linked to Kaposi's sarcoma, certain B-cell lymphomas and cervical cancer, respectively. We discuss the molecular mechanisms by which these viruses subvert the ubiquitin system and potential viral targets for anti-cancer therapy from the perspective of this system. Publication history: Republished from Current BioData's Targeted Proteins database (TPdb; ).
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spelling pubmed-21063722007-12-05 Role of the ubiquitin system and tumor viruses in AIDS-related cancer Shackelford, Julia Pagano, Joseph S BMC Biochem Review Tumor viruses are linked to approximately 20% of human malignancies worldwide. This review focuses on examples of human oncogenic viruses that manipulate the ubiquitin system in a subset of viral malignancies; those associated with AIDS. The viruses include Kaposi's sarcoma herpesvirus, Epstein-Barr virus and human papilloma virus, which are causally linked to Kaposi's sarcoma, certain B-cell lymphomas and cervical cancer, respectively. We discuss the molecular mechanisms by which these viruses subvert the ubiquitin system and potential viral targets for anti-cancer therapy from the perspective of this system. Publication history: Republished from Current BioData's Targeted Proteins database (TPdb; ). BioMed Central 2007-11-22 /pmc/articles/PMC2106372/ /pubmed/18047745 http://dx.doi.org/10.1186/1471-2091-8-S1-S8 Text en Copyright © 2007 Shackelford and Pagano; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Shackelford, Julia
Pagano, Joseph S
Role of the ubiquitin system and tumor viruses in AIDS-related cancer
title Role of the ubiquitin system and tumor viruses in AIDS-related cancer
title_full Role of the ubiquitin system and tumor viruses in AIDS-related cancer
title_fullStr Role of the ubiquitin system and tumor viruses in AIDS-related cancer
title_full_unstemmed Role of the ubiquitin system and tumor viruses in AIDS-related cancer
title_short Role of the ubiquitin system and tumor viruses in AIDS-related cancer
title_sort role of the ubiquitin system and tumor viruses in aids-related cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2106372/
https://www.ncbi.nlm.nih.gov/pubmed/18047745
http://dx.doi.org/10.1186/1471-2091-8-S1-S8
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