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A MORPHOMETRIC STUDY ON THE THICKNESS OF THE PULMONARY AIR-BLOOD BARRIER
A reliable knowledge of the thickness of the alveolo-capillary "membrane" or air-blood barrier is of physiologic interest since it is intimately related to a quantitative estimation of such functional events as gas diffusion or tissue metabolism in the lung. The characteristic thickness of...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1964
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2106384/ https://www.ncbi.nlm.nih.gov/pubmed/14189911 |
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author | Weibel, Ewald R. Knight, Bruce W. |
author_facet | Weibel, Ewald R. Knight, Bruce W. |
author_sort | Weibel, Ewald R. |
collection | PubMed |
description | A reliable knowledge of the thickness of the alveolo-capillary "membrane" or air-blood barrier is of physiologic interest since it is intimately related to a quantitative estimation of such functional events as gas diffusion or tissue metabolism in the lung. The characteristic thickness of the air-blood barrier with respect to gas diffusion is its harmonic mean thickness, while the arithmetic mean thickness is related to the mass of tissue building the barrier and consuming oxygen in the lung. Two morphometric methods are proposed by which these two dimensions can be estimated from random measurements in the electron microscope in a reliable, simple, and efficient manner. By applying these methods to three rat lungs the arithmetic mean thickness of the barrier was found to measure 1.25 µ, the harmonic mean thickness, 0.57 µ. On the basis of these measurements a geometric model of the barrier in the form of a corrugated membrane was derived. Its dimensions showed close similarity to those of the natural barrier. This analysis suggested furthermore that the gas conductance of the barrier is nearly optimal if one considers the mass of tissue and the minimal barrier thickness as fixed properties which are determined by other functional requirements on the alveolo-capillary membrane. |
format | Text |
id | pubmed-2106384 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1964 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21063842008-05-01 A MORPHOMETRIC STUDY ON THE THICKNESS OF THE PULMONARY AIR-BLOOD BARRIER Weibel, Ewald R. Knight, Bruce W. J Cell Biol Article A reliable knowledge of the thickness of the alveolo-capillary "membrane" or air-blood barrier is of physiologic interest since it is intimately related to a quantitative estimation of such functional events as gas diffusion or tissue metabolism in the lung. The characteristic thickness of the air-blood barrier with respect to gas diffusion is its harmonic mean thickness, while the arithmetic mean thickness is related to the mass of tissue building the barrier and consuming oxygen in the lung. Two morphometric methods are proposed by which these two dimensions can be estimated from random measurements in the electron microscope in a reliable, simple, and efficient manner. By applying these methods to three rat lungs the arithmetic mean thickness of the barrier was found to measure 1.25 µ, the harmonic mean thickness, 0.57 µ. On the basis of these measurements a geometric model of the barrier in the form of a corrugated membrane was derived. Its dimensions showed close similarity to those of the natural barrier. This analysis suggested furthermore that the gas conductance of the barrier is nearly optimal if one considers the mass of tissue and the minimal barrier thickness as fixed properties which are determined by other functional requirements on the alveolo-capillary membrane. The Rockefeller University Press 1964-06-01 /pmc/articles/PMC2106384/ /pubmed/14189911 Text en Copyright © 1964 by The Rockefeller Institute Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Weibel, Ewald R. Knight, Bruce W. A MORPHOMETRIC STUDY ON THE THICKNESS OF THE PULMONARY AIR-BLOOD BARRIER |
title | A MORPHOMETRIC STUDY ON THE THICKNESS OF THE PULMONARY AIR-BLOOD BARRIER |
title_full | A MORPHOMETRIC STUDY ON THE THICKNESS OF THE PULMONARY AIR-BLOOD BARRIER |
title_fullStr | A MORPHOMETRIC STUDY ON THE THICKNESS OF THE PULMONARY AIR-BLOOD BARRIER |
title_full_unstemmed | A MORPHOMETRIC STUDY ON THE THICKNESS OF THE PULMONARY AIR-BLOOD BARRIER |
title_short | A MORPHOMETRIC STUDY ON THE THICKNESS OF THE PULMONARY AIR-BLOOD BARRIER |
title_sort | morphometric study on the thickness of the pulmonary air-blood barrier |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2106384/ https://www.ncbi.nlm.nih.gov/pubmed/14189911 |
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