DEGRADATION OF RIBONUCLEIC ACID IN MOUSE FIBROBLASTS TREATED WITH ACTINOMYCIN

The cellular RNA content of mouse fibroblasts incubated with actinomycin decreases at a rate of about 1 to 1.5 per cent per hour, while DNA and protein content remain unchanged. This degradation affects nuclear and cytoplasmic RNA, ribosomal and soluble RNA. The breakdown products appear quantitativ...

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Detalles Bibliográficos
Autores principales: Wiesner, R., Acs, G., Reich, E., Shafiq, A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1965
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2106805/
https://www.ncbi.nlm.nih.gov/pubmed/4159288
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author Wiesner, R.
Acs, G.
Reich, E.
Shafiq, A.
author_facet Wiesner, R.
Acs, G.
Reich, E.
Shafiq, A.
author_sort Wiesner, R.
collection PubMed
description The cellular RNA content of mouse fibroblasts incubated with actinomycin decreases at a rate of about 1 to 1.5 per cent per hour, while DNA and protein content remain unchanged. This degradation affects nuclear and cytoplasmic RNA, ribosomal and soluble RNA. The breakdown products appear quantitatively in the acid-soluble fraction of the cells and the medium. Polynucleotides synthesized a short period (120 minutes) prior to exposure to actinomycin are degraded before those synthesized 8 to 12 hours previously.
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spelling pubmed-21068052008-05-01 DEGRADATION OF RIBONUCLEIC ACID IN MOUSE FIBROBLASTS TREATED WITH ACTINOMYCIN Wiesner, R. Acs, G. Reich, E. Shafiq, A. J Cell Biol Article The cellular RNA content of mouse fibroblasts incubated with actinomycin decreases at a rate of about 1 to 1.5 per cent per hour, while DNA and protein content remain unchanged. This degradation affects nuclear and cytoplasmic RNA, ribosomal and soluble RNA. The breakdown products appear quantitatively in the acid-soluble fraction of the cells and the medium. Polynucleotides synthesized a short period (120 minutes) prior to exposure to actinomycin are degraded before those synthesized 8 to 12 hours previously. The Rockefeller University Press 1965-10-01 /pmc/articles/PMC2106805/ /pubmed/4159288 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Wiesner, R.
Acs, G.
Reich, E.
Shafiq, A.
DEGRADATION OF RIBONUCLEIC ACID IN MOUSE FIBROBLASTS TREATED WITH ACTINOMYCIN
title DEGRADATION OF RIBONUCLEIC ACID IN MOUSE FIBROBLASTS TREATED WITH ACTINOMYCIN
title_full DEGRADATION OF RIBONUCLEIC ACID IN MOUSE FIBROBLASTS TREATED WITH ACTINOMYCIN
title_fullStr DEGRADATION OF RIBONUCLEIC ACID IN MOUSE FIBROBLASTS TREATED WITH ACTINOMYCIN
title_full_unstemmed DEGRADATION OF RIBONUCLEIC ACID IN MOUSE FIBROBLASTS TREATED WITH ACTINOMYCIN
title_short DEGRADATION OF RIBONUCLEIC ACID IN MOUSE FIBROBLASTS TREATED WITH ACTINOMYCIN
title_sort degradation of ribonucleic acid in mouse fibroblasts treated with actinomycin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2106805/
https://www.ncbi.nlm.nih.gov/pubmed/4159288
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AT acsg degradationofribonucleicacidinmousefibroblaststreatedwithactinomycin
AT reiche degradationofribonucleicacidinmousefibroblaststreatedwithactinomycin
AT shafiqa degradationofribonucleicacidinmousefibroblaststreatedwithactinomycin

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