Transposons as tools for enhancer trap screens in vertebrates

DNA transposons are efficient tools in transgenesis and have therefore become popular in the analysis of the regulatory genome in vertebrates via enhancer trap screens. Here, I discuss recent progress in this field of research, with a focus on the application of one of these transposons, namely the...

Descripción completa

Detalles Bibliográficos
Autor principal: Korzh, Vladimir
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2106835/
https://www.ncbi.nlm.nih.gov/pubmed/18047700
http://dx.doi.org/10.1186/gb-2007-8-s1-s8
Descripción
Sumario:DNA transposons are efficient tools in transgenesis and have therefore become popular in the analysis of the regulatory genome in vertebrates via enhancer trap screens. Here, I discuss recent progress in this field of research, with a focus on the application of one of these transposons, namely the medaka fish derived Tol2, to enhancer trapping in zebrafish, and how this approach compares with others that have a similar objective.

Ejemplares similares