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EFFECTS OF ACTINOMYCIN D AND PUROMYCIN ON THE ACTH-INDUCED ULTRASTRUCTURAL TRANSFORMATION OF MITOCHONDRIA OF CORTICAL CELLS OF RAT ADRENALS IN TISSUE CULTURE
The ultrastructure of the mitochondria of the cultured cortical cells of rat adrenals was studied. In vivo it was found that the zona fasciculata mitochondria have vesicular internal structure. 600-A vesicles appear free in the matrix or as protrusions of the inner mitochondrial membrane. In tissue...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1968
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2107337/ https://www.ncbi.nlm.nih.gov/pubmed/19806701 |
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author | Kahri, A. I. |
author_facet | Kahri, A. I. |
author_sort | Kahri, A. I. |
collection | PubMed |
description | The ultrastructure of the mitochondria of the cultured cortical cells of rat adrenals was studied. In vivo it was found that the zona fasciculata mitochondria have vesicular internal structure. 600-A vesicles appear free in the matrix or as protrusions of the inner mitochondrial membrane. In tissue cultures of the fetal and newborn rat adrenal cortex it was seen that ACTH induces transformation of the tubulo-vesicular internal structure of the mitochondria to 600-A vesicles. Actinomycin D and puromycin inhibited this transformation if they were added with ACTH. When added alone, these inhibitors of protein synthesis induced no change in the ultrastructure of the mitochondria in cultured cortical cells of rat adrenals. |
format | Text |
id | pubmed-2107337 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1968 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21073372008-05-01 EFFECTS OF ACTINOMYCIN D AND PUROMYCIN ON THE ACTH-INDUCED ULTRASTRUCTURAL TRANSFORMATION OF MITOCHONDRIA OF CORTICAL CELLS OF RAT ADRENALS IN TISSUE CULTURE Kahri, A. I. J Cell Biol Article The ultrastructure of the mitochondria of the cultured cortical cells of rat adrenals was studied. In vivo it was found that the zona fasciculata mitochondria have vesicular internal structure. 600-A vesicles appear free in the matrix or as protrusions of the inner mitochondrial membrane. In tissue cultures of the fetal and newborn rat adrenal cortex it was seen that ACTH induces transformation of the tubulo-vesicular internal structure of the mitochondria to 600-A vesicles. Actinomycin D and puromycin inhibited this transformation if they were added with ACTH. When added alone, these inhibitors of protein synthesis induced no change in the ultrastructure of the mitochondria in cultured cortical cells of rat adrenals. The Rockefeller University Press 1968-01-01 /pmc/articles/PMC2107337/ /pubmed/19806701 Text en Copyright © 1968 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Kahri, A. I. EFFECTS OF ACTINOMYCIN D AND PUROMYCIN ON THE ACTH-INDUCED ULTRASTRUCTURAL TRANSFORMATION OF MITOCHONDRIA OF CORTICAL CELLS OF RAT ADRENALS IN TISSUE CULTURE |
title | EFFECTS OF ACTINOMYCIN D AND PUROMYCIN ON THE ACTH-INDUCED ULTRASTRUCTURAL TRANSFORMATION OF MITOCHONDRIA OF CORTICAL CELLS OF RAT ADRENALS IN TISSUE CULTURE |
title_full | EFFECTS OF ACTINOMYCIN D AND PUROMYCIN ON THE ACTH-INDUCED ULTRASTRUCTURAL TRANSFORMATION OF MITOCHONDRIA OF CORTICAL CELLS OF RAT ADRENALS IN TISSUE CULTURE |
title_fullStr | EFFECTS OF ACTINOMYCIN D AND PUROMYCIN ON THE ACTH-INDUCED ULTRASTRUCTURAL TRANSFORMATION OF MITOCHONDRIA OF CORTICAL CELLS OF RAT ADRENALS IN TISSUE CULTURE |
title_full_unstemmed | EFFECTS OF ACTINOMYCIN D AND PUROMYCIN ON THE ACTH-INDUCED ULTRASTRUCTURAL TRANSFORMATION OF MITOCHONDRIA OF CORTICAL CELLS OF RAT ADRENALS IN TISSUE CULTURE |
title_short | EFFECTS OF ACTINOMYCIN D AND PUROMYCIN ON THE ACTH-INDUCED ULTRASTRUCTURAL TRANSFORMATION OF MITOCHONDRIA OF CORTICAL CELLS OF RAT ADRENALS IN TISSUE CULTURE |
title_sort | effects of actinomycin d and puromycin on the acth-induced ultrastructural transformation of mitochondria of cortical cells of rat adrenals in tissue culture |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2107337/ https://www.ncbi.nlm.nih.gov/pubmed/19806701 |
work_keys_str_mv | AT kahriai effectsofactinomycindandpuromycinontheacthinducedultrastructuraltransformationofmitochondriaofcorticalcellsofratadrenalsintissueculture |