THE CENTRIOLE CYCLE IN SYNCHRONIZED HELA CELLS

Progression of the HeLa cell through its life cycle is accompanied by centriolar replication and pericentriolar changes that are in synchrony with DNA synthesis and mitosis. The first signs of preparation for replication occur during G(1) at which time the two orthogonal centrioles separate. Replica...

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Detalles Bibliográficos
Autores principales: Robbins, Elliott, Jentzsch, Gisela, Micali, Anita
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1968
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2107360/
https://www.ncbi.nlm.nih.gov/pubmed/5638885
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author Robbins, Elliott
Jentzsch, Gisela
Micali, Anita
author_facet Robbins, Elliott
Jentzsch, Gisela
Micali, Anita
author_sort Robbins, Elliott
collection PubMed
description Progression of the HeLa cell through its life cycle is accompanied by centriolar replication and pericentriolar changes that are in synchrony with DNA synthesis and mitosis. The first signs of preparation for replication occur during G(1) at which time the two orthogonal centrioles separate. Replication by budding begins at/or near the initiation of DNA synthesis and is completed by G(2). Pericentriolar changes which probably are causally related to spindle tubule formation occur at this time and include the appearance of vesicles, electron-opaque bodies, and an amorphous pericentriolar halo. These phenomena begin to disappear by late prophase, and the remainder of mitosis manifests decreasing centriolar and pericentriolar activity.
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spelling pubmed-21073602008-05-01 THE CENTRIOLE CYCLE IN SYNCHRONIZED HELA CELLS Robbins, Elliott Jentzsch, Gisela Micali, Anita J Cell Biol Article Progression of the HeLa cell through its life cycle is accompanied by centriolar replication and pericentriolar changes that are in synchrony with DNA synthesis and mitosis. The first signs of preparation for replication occur during G(1) at which time the two orthogonal centrioles separate. Replication by budding begins at/or near the initiation of DNA synthesis and is completed by G(2). Pericentriolar changes which probably are causally related to spindle tubule formation occur at this time and include the appearance of vesicles, electron-opaque bodies, and an amorphous pericentriolar halo. These phenomena begin to disappear by late prophase, and the remainder of mitosis manifests decreasing centriolar and pericentriolar activity. The Rockefeller University Press 1968-02-01 /pmc/articles/PMC2107360/ /pubmed/5638885 Text en Copyright © 1968 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Robbins, Elliott
Jentzsch, Gisela
Micali, Anita
THE CENTRIOLE CYCLE IN SYNCHRONIZED HELA CELLS
title THE CENTRIOLE CYCLE IN SYNCHRONIZED HELA CELLS
title_full THE CENTRIOLE CYCLE IN SYNCHRONIZED HELA CELLS
title_fullStr THE CENTRIOLE CYCLE IN SYNCHRONIZED HELA CELLS
title_full_unstemmed THE CENTRIOLE CYCLE IN SYNCHRONIZED HELA CELLS
title_short THE CENTRIOLE CYCLE IN SYNCHRONIZED HELA CELLS
title_sort centriole cycle in synchronized hela cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2107360/
https://www.ncbi.nlm.nih.gov/pubmed/5638885
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