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HUMAN WOUND REPAIR : I. Epidermal Regeneration

A series of linearly incised superficial skin wounds was made on the forearms of young adult male volunteers. Wounds were sampled at several intervals between 3 hr and 21 days after wounding, for study by light and electron microscopy. The light microscopic observations show that regeneration of epi...

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Detalles Bibliográficos
Autores principales: Odland, George, Ross, Russell
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1968
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2107509/
https://www.ncbi.nlm.nih.gov/pubmed/5678445
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author Odland, George
Ross, Russell
author_facet Odland, George
Ross, Russell
author_sort Odland, George
collection PubMed
description A series of linearly incised superficial skin wounds was made on the forearms of young adult male volunteers. Wounds were sampled at several intervals between 3 hr and 21 days after wounding, for study by light and electron microscopy. The light microscopic observations show that regeneration of epidermis in human wounds conforms chronologically to that reported for the epidermis in superficial wound repair in laboratory animals. It is further shown that "ruffling" of cell membranes characterizes the cells of the migrating epidermis in early wound healing. This study reveals that the basement lamina and hemidesmosomes are established by epidermis in contact with the fibrin net at the base of early wounds. Epidermal cells in the wound environment are shown to be phagocytic. Analysis of the submicroscopic cytology of differentiating and maturing regenerated epidermis reveals that, in the sequence of events, the formation of filaments, basal lamina, and desmosomes is followed chronologically by evolution of keratohyalin granules and, subsequently, by keratinization of the surface epidermal elements. The entire sequence of migration, differentiation, and ultimate keratinization in the superficial wounds studied requires 3–5 days for completion.
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spelling pubmed-21075092008-05-01 HUMAN WOUND REPAIR : I. Epidermal Regeneration Odland, George Ross, Russell J Cell Biol Article A series of linearly incised superficial skin wounds was made on the forearms of young adult male volunteers. Wounds were sampled at several intervals between 3 hr and 21 days after wounding, for study by light and electron microscopy. The light microscopic observations show that regeneration of epidermis in human wounds conforms chronologically to that reported for the epidermis in superficial wound repair in laboratory animals. It is further shown that "ruffling" of cell membranes characterizes the cells of the migrating epidermis in early wound healing. This study reveals that the basement lamina and hemidesmosomes are established by epidermis in contact with the fibrin net at the base of early wounds. Epidermal cells in the wound environment are shown to be phagocytic. Analysis of the submicroscopic cytology of differentiating and maturing regenerated epidermis reveals that, in the sequence of events, the formation of filaments, basal lamina, and desmosomes is followed chronologically by evolution of keratohyalin granules and, subsequently, by keratinization of the surface epidermal elements. The entire sequence of migration, differentiation, and ultimate keratinization in the superficial wounds studied requires 3–5 days for completion. The Rockefeller University Press 1968-10-01 /pmc/articles/PMC2107509/ /pubmed/5678445 Text en Copyright © 1968 by The Rockefeller University Press. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Odland, George
Ross, Russell
HUMAN WOUND REPAIR : I. Epidermal Regeneration
title HUMAN WOUND REPAIR : I. Epidermal Regeneration
title_full HUMAN WOUND REPAIR : I. Epidermal Regeneration
title_fullStr HUMAN WOUND REPAIR : I. Epidermal Regeneration
title_full_unstemmed HUMAN WOUND REPAIR : I. Epidermal Regeneration
title_short HUMAN WOUND REPAIR : I. Epidermal Regeneration
title_sort human wound repair : i. epidermal regeneration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2107509/
https://www.ncbi.nlm.nih.gov/pubmed/5678445
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