INTESTINAL CAPILLARIES : II. Structural Effects of EDTA and Histamine

Perfusion of the fenestrated capillaries of the intestinal mucosa of the rat with 0.05–0.1 M EDTA removes the diaphragms of the endothelial cells and detaches these cells from one another and from the basement membrane. The latter, even when completely denuded, retains effectively particles of 340 A...

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Detalles Bibliográficos
Autores principales: Clementi, Francesco, Palade, George E.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1969
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2107705/
https://www.ncbi.nlm.nih.gov/pubmed/4979362
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author Clementi, Francesco
Palade, George E.
author_facet Clementi, Francesco
Palade, George E.
author_sort Clementi, Francesco
collection PubMed
description Perfusion of the fenestrated capillaries of the intestinal mucosa of the rat with 0.05–0.1 M EDTA removes the diaphragms of the endothelial cells and detaches these cells from one another and from the basement membrane. The latter, even when completely denuded, retains effectively particles of 340 A (average) diameter. Perfusion with histamine (1 µg/ml) results in partial removal of fenestral diaphragms, occasional detachment of the endothelium from the basement membrane, and focal separation of endothelial intercellular junctions.
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spelling pubmed-21077052008-05-01 INTESTINAL CAPILLARIES : II. Structural Effects of EDTA and Histamine Clementi, Francesco Palade, George E. J Cell Biol Article Perfusion of the fenestrated capillaries of the intestinal mucosa of the rat with 0.05–0.1 M EDTA removes the diaphragms of the endothelial cells and detaches these cells from one another and from the basement membrane. The latter, even when completely denuded, retains effectively particles of 340 A (average) diameter. Perfusion with histamine (1 µg/ml) results in partial removal of fenestral diaphragms, occasional detachment of the endothelium from the basement membrane, and focal separation of endothelial intercellular junctions. The Rockefeller University Press 1969-09-01 /pmc/articles/PMC2107705/ /pubmed/4979362 Text en Copyright © 1969 by The Rockefeller University Press. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Clementi, Francesco
Palade, George E.
INTESTINAL CAPILLARIES : II. Structural Effects of EDTA and Histamine
title INTESTINAL CAPILLARIES : II. Structural Effects of EDTA and Histamine
title_full INTESTINAL CAPILLARIES : II. Structural Effects of EDTA and Histamine
title_fullStr INTESTINAL CAPILLARIES : II. Structural Effects of EDTA and Histamine
title_full_unstemmed INTESTINAL CAPILLARIES : II. Structural Effects of EDTA and Histamine
title_short INTESTINAL CAPILLARIES : II. Structural Effects of EDTA and Histamine
title_sort intestinal capillaries : ii. structural effects of edta and histamine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2107705/
https://www.ncbi.nlm.nih.gov/pubmed/4979362
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