THE OUTWARD TRANSPORT OF CORTISOL BY MAMMALIAN CELLS IN VITRO

It has been determined that cortisol and a few other steroids are transported outward from certain mammalian cells growing in vitro. The extrusion process is temperature dependent, glucose dependent, saturable, and operates for only a few selected steroids. Many, but not all, steroids are able to bl...

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Detalles Bibliográficos
Autores principales: Gross, Stephen R., Aronow, Lewis, Pratt, William B.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1970
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2107792/
https://www.ncbi.nlm.nih.gov/pubmed/4242926
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author Gross, Stephen R.
Aronow, Lewis
Pratt, William B.
author_facet Gross, Stephen R.
Aronow, Lewis
Pratt, William B.
author_sort Gross, Stephen R.
collection PubMed
description It has been determined that cortisol and a few other steroids are transported outward from certain mammalian cells growing in vitro. The extrusion process is temperature dependent, glucose dependent, saturable, and operates for only a few selected steroids. Many, but not all, steroids are able to block the extrusion process but are not themselves transported. The outward transport process for steroids has been found in mouse fibroblasts, mouse lymphoma cells, and functional mouse adrenal gland tumor cells growing in vitro. The transport process is not present in two varieties of cells cultured from human sources—HeLa or diploid fibroblasts, WI-38.
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spelling pubmed-21077922008-05-01 THE OUTWARD TRANSPORT OF CORTISOL BY MAMMALIAN CELLS IN VITRO Gross, Stephen R. Aronow, Lewis Pratt, William B. J Cell Biol Article It has been determined that cortisol and a few other steroids are transported outward from certain mammalian cells growing in vitro. The extrusion process is temperature dependent, glucose dependent, saturable, and operates for only a few selected steroids. Many, but not all, steroids are able to block the extrusion process but are not themselves transported. The outward transport process for steroids has been found in mouse fibroblasts, mouse lymphoma cells, and functional mouse adrenal gland tumor cells growing in vitro. The transport process is not present in two varieties of cells cultured from human sources—HeLa or diploid fibroblasts, WI-38. The Rockefeller University Press 1970-01-01 /pmc/articles/PMC2107792/ /pubmed/4242926 Text en Copyright © 1970 by The Rockefeller University Press. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Gross, Stephen R.
Aronow, Lewis
Pratt, William B.
THE OUTWARD TRANSPORT OF CORTISOL BY MAMMALIAN CELLS IN VITRO
title THE OUTWARD TRANSPORT OF CORTISOL BY MAMMALIAN CELLS IN VITRO
title_full THE OUTWARD TRANSPORT OF CORTISOL BY MAMMALIAN CELLS IN VITRO
title_fullStr THE OUTWARD TRANSPORT OF CORTISOL BY MAMMALIAN CELLS IN VITRO
title_full_unstemmed THE OUTWARD TRANSPORT OF CORTISOL BY MAMMALIAN CELLS IN VITRO
title_short THE OUTWARD TRANSPORT OF CORTISOL BY MAMMALIAN CELLS IN VITRO
title_sort outward transport of cortisol by mammalian cells in vitro
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2107792/
https://www.ncbi.nlm.nih.gov/pubmed/4242926
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