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LYSOZYME IN EPIPHYSEAL CARTILAGE : II. The Effect of Egg White Lysozyme on Mouse Embryonic Femurs in Organ Cultures
Embryonic mouse femoral cartilage, like the epiphyseal cartilage of the calf scapula, contains large amounts of lysozyme. The addition of egg white lysozyme to organ cultures of embryonic mouse femurs induces unique alterations in the gross and microscopic morphology of the femurs. The sites of thes...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1970
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2107949/ https://www.ncbi.nlm.nih.gov/pubmed/5460753 |
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author | Kuettner, K. E. Soble, L. W. Ray, R. D. Croxen, R. L. Passovoy, M. Eisenstein, R. |
author_facet | Kuettner, K. E. Soble, L. W. Ray, R. D. Croxen, R. L. Passovoy, M. Eisenstein, R. |
author_sort | Kuettner, K. E. |
collection | PubMed |
description | Embryonic mouse femoral cartilage, like the epiphyseal cartilage of the calf scapula, contains large amounts of lysozyme. The addition of egg white lysozyme to organ cultures of embryonic mouse femurs induces unique alterations in the gross and microscopic morphology of the femurs. The sites of these alterations are precisely related to the natural distribution of lysozyme in calf scapula. If the exogenous lysozyme is withdrawn from the culture, the morphological changes disappear, accompanied by a resumption or derepression of growth. The effect on growth is evident only in 17-day embryos. These observations support the idea that lysozyme has a physiological role in cartilage, perhaps related to a regulatory mechanism in bone formation. |
format | Text |
id | pubmed-2107949 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1970 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21079492008-05-01 LYSOZYME IN EPIPHYSEAL CARTILAGE : II. The Effect of Egg White Lysozyme on Mouse Embryonic Femurs in Organ Cultures Kuettner, K. E. Soble, L. W. Ray, R. D. Croxen, R. L. Passovoy, M. Eisenstein, R. J Cell Biol Article Embryonic mouse femoral cartilage, like the epiphyseal cartilage of the calf scapula, contains large amounts of lysozyme. The addition of egg white lysozyme to organ cultures of embryonic mouse femurs induces unique alterations in the gross and microscopic morphology of the femurs. The sites of these alterations are precisely related to the natural distribution of lysozyme in calf scapula. If the exogenous lysozyme is withdrawn from the culture, the morphological changes disappear, accompanied by a resumption or derepression of growth. The effect on growth is evident only in 17-day embryos. These observations support the idea that lysozyme has a physiological role in cartilage, perhaps related to a regulatory mechanism in bone formation. The Rockefeller University Press 1970-02-01 /pmc/articles/PMC2107949/ /pubmed/5460753 Text en Copyright © 1970 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Kuettner, K. E. Soble, L. W. Ray, R. D. Croxen, R. L. Passovoy, M. Eisenstein, R. LYSOZYME IN EPIPHYSEAL CARTILAGE : II. The Effect of Egg White Lysozyme on Mouse Embryonic Femurs in Organ Cultures |
title | LYSOZYME IN EPIPHYSEAL CARTILAGE : II. The Effect of Egg White Lysozyme on Mouse Embryonic Femurs in Organ Cultures |
title_full | LYSOZYME IN EPIPHYSEAL CARTILAGE : II. The Effect of Egg White Lysozyme on Mouse Embryonic Femurs in Organ Cultures |
title_fullStr | LYSOZYME IN EPIPHYSEAL CARTILAGE : II. The Effect of Egg White Lysozyme on Mouse Embryonic Femurs in Organ Cultures |
title_full_unstemmed | LYSOZYME IN EPIPHYSEAL CARTILAGE : II. The Effect of Egg White Lysozyme on Mouse Embryonic Femurs in Organ Cultures |
title_short | LYSOZYME IN EPIPHYSEAL CARTILAGE : II. The Effect of Egg White Lysozyme on Mouse Embryonic Femurs in Organ Cultures |
title_sort | lysozyme in epiphyseal cartilage : ii. the effect of egg white lysozyme on mouse embryonic femurs in organ cultures |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2107949/ https://www.ncbi.nlm.nih.gov/pubmed/5460753 |
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