THE EFFECT OF PROTEIN SYNTHESIS INHIBITION ON THE ENTRY OF MESSENGER RNA INTO THE CYTOPLASM OF SEA URCHIN EMBRYOS

Emetine is a potent inhibitor of protein synthesis in sea urchin embryos. At a concentration of the drug that rapidly inhibits protein synthesis in blastulae by 95%, uridine incorporation into RNA continues for more than 1 hr and presumptive histone messenger RNA is synthesized and transported into...

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Detalles Bibliográficos
Autores principales: Hogan, Brigid, Gross, Paul R.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1971
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2108483/
https://www.ncbi.nlm.nih.gov/pubmed/4997172
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author Hogan, Brigid
Gross, Paul R.
author_facet Hogan, Brigid
Gross, Paul R.
author_sort Hogan, Brigid
collection PubMed
description Emetine is a potent inhibitor of protein synthesis in sea urchin embryos. At a concentration of the drug that rapidly inhibits protein synthesis in blastulae by 95%, uridine incorporation into RNA continues for more than 1 hr and presumptive histone messenger RNA is synthesized and transported into the cytoplasm where it is apparently associated with polyribosomes. Possible explanations of this result and its implications for the "informasome" theory of messenger transport in embryonic cells are discussed.
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spelling pubmed-21084832008-05-01 THE EFFECT OF PROTEIN SYNTHESIS INHIBITION ON THE ENTRY OF MESSENGER RNA INTO THE CYTOPLASM OF SEA URCHIN EMBRYOS Hogan, Brigid Gross, Paul R. J Cell Biol Article Emetine is a potent inhibitor of protein synthesis in sea urchin embryos. At a concentration of the drug that rapidly inhibits protein synthesis in blastulae by 95%, uridine incorporation into RNA continues for more than 1 hr and presumptive histone messenger RNA is synthesized and transported into the cytoplasm where it is apparently associated with polyribosomes. Possible explanations of this result and its implications for the "informasome" theory of messenger transport in embryonic cells are discussed. The Rockefeller University Press 1971-06-01 /pmc/articles/PMC2108483/ /pubmed/4997172 Text en Copyright © 1971 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Hogan, Brigid
Gross, Paul R.
THE EFFECT OF PROTEIN SYNTHESIS INHIBITION ON THE ENTRY OF MESSENGER RNA INTO THE CYTOPLASM OF SEA URCHIN EMBRYOS
title THE EFFECT OF PROTEIN SYNTHESIS INHIBITION ON THE ENTRY OF MESSENGER RNA INTO THE CYTOPLASM OF SEA URCHIN EMBRYOS
title_full THE EFFECT OF PROTEIN SYNTHESIS INHIBITION ON THE ENTRY OF MESSENGER RNA INTO THE CYTOPLASM OF SEA URCHIN EMBRYOS
title_fullStr THE EFFECT OF PROTEIN SYNTHESIS INHIBITION ON THE ENTRY OF MESSENGER RNA INTO THE CYTOPLASM OF SEA URCHIN EMBRYOS
title_full_unstemmed THE EFFECT OF PROTEIN SYNTHESIS INHIBITION ON THE ENTRY OF MESSENGER RNA INTO THE CYTOPLASM OF SEA URCHIN EMBRYOS
title_short THE EFFECT OF PROTEIN SYNTHESIS INHIBITION ON THE ENTRY OF MESSENGER RNA INTO THE CYTOPLASM OF SEA URCHIN EMBRYOS
title_sort effect of protein synthesis inhibition on the entry of messenger rna into the cytoplasm of sea urchin embryos
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2108483/
https://www.ncbi.nlm.nih.gov/pubmed/4997172
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