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REPAIR DNA SYNTHESIS IN DIFFERENTIATED EMBRYONIC MUSCLE CELLS
The differentiation of embryonic skeletal muscle cells is closely coupled with the cessation of normal DNA replication. Once these cells begin to differentiate, they normally never undergo semiconservative replication of DNA during the entire life time of the muscle cell. Cessation of DNA synthesis...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1972
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2108667/ https://www.ncbi.nlm.nih.gov/pubmed/5009521 |
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author | Stockdale, Frank E. O'neill, Michael C. |
author_facet | Stockdale, Frank E. O'neill, Michael C. |
author_sort | Stockdale, Frank E. |
collection | PubMed |
description | The differentiation of embryonic skeletal muscle cells is closely coupled with the cessation of normal DNA replication. Once these cells begin to differentiate, they normally never undergo semiconservative replication of DNA during the entire life time of the muscle cell. Cessation of DNA synthesis has been shown to be accompanied by a loss of 80–90% of the replicative DNA polymerase activity of these cells. Despite this loss the studies reported here demonstrate that muscle cells retain the ability to synthesize DNA of a repair type after UV irradiation. These results suggest that the control exercised over semiconservative DNA synthesis during differentiation of these cells does not extend to repair synthesis after UV irradiation. |
format | Text |
id | pubmed-2108667 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1972 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21086672008-05-01 REPAIR DNA SYNTHESIS IN DIFFERENTIATED EMBRYONIC MUSCLE CELLS Stockdale, Frank E. O'neill, Michael C. J Cell Biol Article The differentiation of embryonic skeletal muscle cells is closely coupled with the cessation of normal DNA replication. Once these cells begin to differentiate, they normally never undergo semiconservative replication of DNA during the entire life time of the muscle cell. Cessation of DNA synthesis has been shown to be accompanied by a loss of 80–90% of the replicative DNA polymerase activity of these cells. Despite this loss the studies reported here demonstrate that muscle cells retain the ability to synthesize DNA of a repair type after UV irradiation. These results suggest that the control exercised over semiconservative DNA synthesis during differentiation of these cells does not extend to repair synthesis after UV irradiation. The Rockefeller University Press 1972-03-01 /pmc/articles/PMC2108667/ /pubmed/5009521 Text en Copyright © 1972 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Stockdale, Frank E. O'neill, Michael C. REPAIR DNA SYNTHESIS IN DIFFERENTIATED EMBRYONIC MUSCLE CELLS |
title | REPAIR DNA SYNTHESIS IN DIFFERENTIATED EMBRYONIC MUSCLE CELLS |
title_full | REPAIR DNA SYNTHESIS IN DIFFERENTIATED EMBRYONIC MUSCLE CELLS |
title_fullStr | REPAIR DNA SYNTHESIS IN DIFFERENTIATED EMBRYONIC MUSCLE CELLS |
title_full_unstemmed | REPAIR DNA SYNTHESIS IN DIFFERENTIATED EMBRYONIC MUSCLE CELLS |
title_short | REPAIR DNA SYNTHESIS IN DIFFERENTIATED EMBRYONIC MUSCLE CELLS |
title_sort | repair dna synthesis in differentiated embryonic muscle cells |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2108667/ https://www.ncbi.nlm.nih.gov/pubmed/5009521 |
work_keys_str_mv | AT stockdalefranke repairdnasynthesisindifferentiatedembryonicmusclecells AT oneillmichaelc repairdnasynthesisindifferentiatedembryonicmusclecells |