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CELL SURFACE CHANGES DURING DEDIFFERENTIATION IN THE METAPLASTIC TRANSFORMATION OF IRIS INTO LENS
Changes at the cell periphery during the dedifferentiative phase of the metaplastic transformation of iris into lens have been studied in Notophthalmus viridescens and Taricha granulosa using cell electrophoresis. Cell surface charge density increases as early as 1–3 days after lens removal. Cells o...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1972
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2108761/ https://www.ncbi.nlm.nih.gov/pubmed/4653413 |
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author | Zalik, Sara E. Scott, Vi |
author_facet | Zalik, Sara E. Scott, Vi |
author_sort | Zalik, Sara E. |
collection | PubMed |
description | Changes at the cell periphery during the dedifferentiative phase of the metaplastic transformation of iris into lens have been studied in Notophthalmus viridescens and Taricha granulosa using cell electrophoresis. Cell surface charge density increases as early as 1–3 days after lens removal. Cells of regenerates at 10–15 days after lentectomy have significantly lower electrophoretic mobilities than those of the irises of nonlentectomized newts. Decrease in surface charge density is due, at least in part, to the loss of ribonuclease- and neuraminidase-sensitive groups from the cell periphery. Loss of negatively charged groups from the cell surface appears to occur as cells go through dedifferentiation. Loss of cell surface components also occurs in the cells of the ventral iris which also undergo dedifFerentiation but do not regenerate a lens. |
format | Text |
id | pubmed-2108761 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1972 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21087612008-05-01 CELL SURFACE CHANGES DURING DEDIFFERENTIATION IN THE METAPLASTIC TRANSFORMATION OF IRIS INTO LENS Zalik, Sara E. Scott, Vi J Cell Biol Article Changes at the cell periphery during the dedifferentiative phase of the metaplastic transformation of iris into lens have been studied in Notophthalmus viridescens and Taricha granulosa using cell electrophoresis. Cell surface charge density increases as early as 1–3 days after lens removal. Cells of regenerates at 10–15 days after lentectomy have significantly lower electrophoretic mobilities than those of the irises of nonlentectomized newts. Decrease in surface charge density is due, at least in part, to the loss of ribonuclease- and neuraminidase-sensitive groups from the cell periphery. Loss of negatively charged groups from the cell surface appears to occur as cells go through dedifferentiation. Loss of cell surface components also occurs in the cells of the ventral iris which also undergo dedifFerentiation but do not regenerate a lens. The Rockefeller University Press 1972-10-01 /pmc/articles/PMC2108761/ /pubmed/4653413 Text en Copyright © 1972 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Zalik, Sara E. Scott, Vi CELL SURFACE CHANGES DURING DEDIFFERENTIATION IN THE METAPLASTIC TRANSFORMATION OF IRIS INTO LENS |
title | CELL SURFACE CHANGES DURING DEDIFFERENTIATION IN THE METAPLASTIC TRANSFORMATION OF IRIS INTO LENS |
title_full | CELL SURFACE CHANGES DURING DEDIFFERENTIATION IN THE METAPLASTIC TRANSFORMATION OF IRIS INTO LENS |
title_fullStr | CELL SURFACE CHANGES DURING DEDIFFERENTIATION IN THE METAPLASTIC TRANSFORMATION OF IRIS INTO LENS |
title_full_unstemmed | CELL SURFACE CHANGES DURING DEDIFFERENTIATION IN THE METAPLASTIC TRANSFORMATION OF IRIS INTO LENS |
title_short | CELL SURFACE CHANGES DURING DEDIFFERENTIATION IN THE METAPLASTIC TRANSFORMATION OF IRIS INTO LENS |
title_sort | cell surface changes during dedifferentiation in the metaplastic transformation of iris into lens |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2108761/ https://www.ncbi.nlm.nih.gov/pubmed/4653413 |
work_keys_str_mv | AT zaliksarae cellsurfacechangesduringdedifferentiationinthemetaplastictransformationofirisintolens AT scottvi cellsurfacechangesduringdedifferentiationinthemetaplastictransformationofirisintolens |