DEVELOPMENT OF PHENOBARBITAL-SENSITIVE CONTROL MECHANISMS FOR URIDINE DIPHOSPHATE GLUCURONYLTRANSFERASE ACTIVITY IN CHICK EMBRYO LIVER

Uridine diphosphate (UDP) glucuronyltransferase activity in chick liver rises at hatching from near zero to adult levels. This rise will occur prematurely in embryo liver during organ culture. Increase in enzyme activity during organ culture differs with embryo age: in liver from 11-day old embryos...

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Detalles Bibliográficos
Autores principales: Burchell, Brian, Dutton, Geoffrey J., Nemeth, Andrew M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1972
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2108804/
https://www.ncbi.nlm.nih.gov/pubmed/5076783
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author Burchell, Brian
Dutton, Geoffrey J.
Nemeth, Andrew M.
author_facet Burchell, Brian
Dutton, Geoffrey J.
Nemeth, Andrew M.
author_sort Burchell, Brian
collection PubMed
description Uridine diphosphate (UDP) glucuronyltransferase activity in chick liver rises at hatching from near zero to adult levels. This rise will occur prematurely in embryo liver during organ culture. Increase in enzyme activity during organ culture differs with embryo age: in liver from 11-day old embryos it ceases at adult values; in liver from 5-day old embryos it continues to much higher-than-adult levels. Phenobarbital added to culture medium accelerates these rises in enzyme activity and elevates the plateau reached in 11-day embryo liver to that observed in 5-day embryo liver. Kinetic analysis of the changes in enzyme activity induced by phenobarbital during culture suggests that the regulatory mechanisms for enzyme activity are different in 5- and 11-day embryo liver and that these differences reflect developmental changes occurring in ovo.
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spelling pubmed-21088042008-05-01 DEVELOPMENT OF PHENOBARBITAL-SENSITIVE CONTROL MECHANISMS FOR URIDINE DIPHOSPHATE GLUCURONYLTRANSFERASE ACTIVITY IN CHICK EMBRYO LIVER Burchell, Brian Dutton, Geoffrey J. Nemeth, Andrew M. J Cell Biol Article Uridine diphosphate (UDP) glucuronyltransferase activity in chick liver rises at hatching from near zero to adult levels. This rise will occur prematurely in embryo liver during organ culture. Increase in enzyme activity during organ culture differs with embryo age: in liver from 11-day old embryos it ceases at adult values; in liver from 5-day old embryos it continues to much higher-than-adult levels. Phenobarbital added to culture medium accelerates these rises in enzyme activity and elevates the plateau reached in 11-day embryo liver to that observed in 5-day embryo liver. Kinetic analysis of the changes in enzyme activity induced by phenobarbital during culture suggests that the regulatory mechanisms for enzyme activity are different in 5- and 11-day embryo liver and that these differences reflect developmental changes occurring in ovo. The Rockefeller University Press 1972-11-01 /pmc/articles/PMC2108804/ /pubmed/5076783 Text en Copyright © 1972 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Burchell, Brian
Dutton, Geoffrey J.
Nemeth, Andrew M.
DEVELOPMENT OF PHENOBARBITAL-SENSITIVE CONTROL MECHANISMS FOR URIDINE DIPHOSPHATE GLUCURONYLTRANSFERASE ACTIVITY IN CHICK EMBRYO LIVER
title DEVELOPMENT OF PHENOBARBITAL-SENSITIVE CONTROL MECHANISMS FOR URIDINE DIPHOSPHATE GLUCURONYLTRANSFERASE ACTIVITY IN CHICK EMBRYO LIVER
title_full DEVELOPMENT OF PHENOBARBITAL-SENSITIVE CONTROL MECHANISMS FOR URIDINE DIPHOSPHATE GLUCURONYLTRANSFERASE ACTIVITY IN CHICK EMBRYO LIVER
title_fullStr DEVELOPMENT OF PHENOBARBITAL-SENSITIVE CONTROL MECHANISMS FOR URIDINE DIPHOSPHATE GLUCURONYLTRANSFERASE ACTIVITY IN CHICK EMBRYO LIVER
title_full_unstemmed DEVELOPMENT OF PHENOBARBITAL-SENSITIVE CONTROL MECHANISMS FOR URIDINE DIPHOSPHATE GLUCURONYLTRANSFERASE ACTIVITY IN CHICK EMBRYO LIVER
title_short DEVELOPMENT OF PHENOBARBITAL-SENSITIVE CONTROL MECHANISMS FOR URIDINE DIPHOSPHATE GLUCURONYLTRANSFERASE ACTIVITY IN CHICK EMBRYO LIVER
title_sort development of phenobarbital-sensitive control mechanisms for uridine diphosphate glucuronyltransferase activity in chick embryo liver
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2108804/
https://www.ncbi.nlm.nih.gov/pubmed/5076783
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AT duttongeoffreyj developmentofphenobarbitalsensitivecontrolmechanismsforuridinediphosphateglucuronyltransferaseactivityinchickembryoliver
AT nemethandrewm developmentofphenobarbitalsensitivecontrolmechanismsforuridinediphosphateglucuronyltransferaseactivityinchickembryoliver

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