CHARACTERIZATION OF RAT LIVER SUBCELLULAR MEMBRANES : Demonstration of Membrane-Specific Autoantigens

The induction of acute hepatocellular necrosis in rats resulted in the production of complement fixing, IgM autoantibodies directed toward inner and outer mitochondrial membranes, microsomal membrane, lysosomal membrane, nuclear membrane, cytosol, but not to plasma membrane. Utilizing selective abso...

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Detalles Bibliográficos
Autores principales: DeHeer, David H., Olson, Merle S., Pinckard, R. Neal
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1974
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2109171/
https://www.ncbi.nlm.nih.gov/pubmed/4813214
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author DeHeer, David H.
Olson, Merle S.
Pinckard, R. Neal
author_facet DeHeer, David H.
Olson, Merle S.
Pinckard, R. Neal
author_sort DeHeer, David H.
collection PubMed
description The induction of acute hepatocellular necrosis in rats resulted in the production of complement fixing, IgM autoantibodies directed toward inner and outer mitochondrial membranes, microsomal membrane, lysosomal membrane, nuclear membrane, cytosol, but not to plasma membrane. Utilizing selective absorption procedures it was demonstrated that each subcellular membrane fraction possessed unique autoantigenic activity with little or no cross-reactivity between the various membrane fractions. It is proposed that the development of membrane-specific autoantibodies may provide an immunological marker useful in the differential characterization of various subcellular membranes.
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spelling pubmed-21091712008-05-01 CHARACTERIZATION OF RAT LIVER SUBCELLULAR MEMBRANES : Demonstration of Membrane-Specific Autoantigens DeHeer, David H. Olson, Merle S. Pinckard, R. Neal J Cell Biol Article The induction of acute hepatocellular necrosis in rats resulted in the production of complement fixing, IgM autoantibodies directed toward inner and outer mitochondrial membranes, microsomal membrane, lysosomal membrane, nuclear membrane, cytosol, but not to plasma membrane. Utilizing selective absorption procedures it was demonstrated that each subcellular membrane fraction possessed unique autoantigenic activity with little or no cross-reactivity between the various membrane fractions. It is proposed that the development of membrane-specific autoantibodies may provide an immunological marker useful in the differential characterization of various subcellular membranes. The Rockefeller University Press 1974-02-01 /pmc/articles/PMC2109171/ /pubmed/4813214 Text en Copyright © 1974 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
DeHeer, David H.
Olson, Merle S.
Pinckard, R. Neal
CHARACTERIZATION OF RAT LIVER SUBCELLULAR MEMBRANES : Demonstration of Membrane-Specific Autoantigens
title CHARACTERIZATION OF RAT LIVER SUBCELLULAR MEMBRANES : Demonstration of Membrane-Specific Autoantigens
title_full CHARACTERIZATION OF RAT LIVER SUBCELLULAR MEMBRANES : Demonstration of Membrane-Specific Autoantigens
title_fullStr CHARACTERIZATION OF RAT LIVER SUBCELLULAR MEMBRANES : Demonstration of Membrane-Specific Autoantigens
title_full_unstemmed CHARACTERIZATION OF RAT LIVER SUBCELLULAR MEMBRANES : Demonstration of Membrane-Specific Autoantigens
title_short CHARACTERIZATION OF RAT LIVER SUBCELLULAR MEMBRANES : Demonstration of Membrane-Specific Autoantigens
title_sort characterization of rat liver subcellular membranes : demonstration of membrane-specific autoantigens
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2109171/
https://www.ncbi.nlm.nih.gov/pubmed/4813214
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AT pinckardrneal characterizationofratliversubcellularmembranesdemonstrationofmembranespecificautoantigens

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