RAPID CHANGES IN NUCLEOSIDE TRANSPORT INDUCED BY GROWTH INHIBITORS : Studies with Neoplastic Mast Cells

Aqueous extracts of murine embryonic or uterine tissue, or [(6)N]O(2)'-dibutyryl 3',5'-adenosine monophosphate (dbc-AMP) which were cytostatic for the murine mastocytoma P815Y in vitro also induced rapid changes in the incorporation of exogenous nucleosides into acid-insoluble materia...

Descripción completa

Detalles Bibliográficos
Autores principales: Lingwood, Clifford A., Thomas, D. Brian
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1974
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2109282/
https://www.ncbi.nlm.nih.gov/pubmed/4363956
_version_ 1782139251106775040
author Lingwood, Clifford A.
Thomas, D. Brian
author_facet Lingwood, Clifford A.
Thomas, D. Brian
author_sort Lingwood, Clifford A.
collection PubMed
description Aqueous extracts of murine embryonic or uterine tissue, or [(6)N]O(2)'-dibutyryl 3',5'-adenosine monophosphate (dbc-AMP) which were cytostatic for the murine mastocytoma P815Y in vitro also induced rapid changes in the incorporation of exogenous nucleosides into acid-insoluble material. However, these alterations were not a consequence of growth arrest. Different dose-response curves were obtained for cytostasis and inhibition of [(3)H]-nucleoside incorporation, and changes in [(3)H]thymidine uptake were detected within 15 min of treatment with the inhibitors. Also, there were differential effects of each inhibitor on the incorporation of (3)H-labeled thymidine, uridine, adenosine, or choline into acid-insoluble material.
format Text
id pubmed-2109282
institution National Center for Biotechnology Information
language English
publishDate 1974
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21092822008-05-01 RAPID CHANGES IN NUCLEOSIDE TRANSPORT INDUCED BY GROWTH INHIBITORS : Studies with Neoplastic Mast Cells Lingwood, Clifford A. Thomas, D. Brian J Cell Biol Article Aqueous extracts of murine embryonic or uterine tissue, or [(6)N]O(2)'-dibutyryl 3',5'-adenosine monophosphate (dbc-AMP) which were cytostatic for the murine mastocytoma P815Y in vitro also induced rapid changes in the incorporation of exogenous nucleosides into acid-insoluble material. However, these alterations were not a consequence of growth arrest. Different dose-response curves were obtained for cytostasis and inhibition of [(3)H]-nucleoside incorporation, and changes in [(3)H]thymidine uptake were detected within 15 min of treatment with the inhibitors. Also, there were differential effects of each inhibitor on the incorporation of (3)H-labeled thymidine, uridine, adenosine, or choline into acid-insoluble material. The Rockefeller University Press 1974-05-01 /pmc/articles/PMC2109282/ /pubmed/4363956 Text en Copyright © 1974 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Lingwood, Clifford A.
Thomas, D. Brian
RAPID CHANGES IN NUCLEOSIDE TRANSPORT INDUCED BY GROWTH INHIBITORS : Studies with Neoplastic Mast Cells
title RAPID CHANGES IN NUCLEOSIDE TRANSPORT INDUCED BY GROWTH INHIBITORS : Studies with Neoplastic Mast Cells
title_full RAPID CHANGES IN NUCLEOSIDE TRANSPORT INDUCED BY GROWTH INHIBITORS : Studies with Neoplastic Mast Cells
title_fullStr RAPID CHANGES IN NUCLEOSIDE TRANSPORT INDUCED BY GROWTH INHIBITORS : Studies with Neoplastic Mast Cells
title_full_unstemmed RAPID CHANGES IN NUCLEOSIDE TRANSPORT INDUCED BY GROWTH INHIBITORS : Studies with Neoplastic Mast Cells
title_short RAPID CHANGES IN NUCLEOSIDE TRANSPORT INDUCED BY GROWTH INHIBITORS : Studies with Neoplastic Mast Cells
title_sort rapid changes in nucleoside transport induced by growth inhibitors : studies with neoplastic mast cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2109282/
https://www.ncbi.nlm.nih.gov/pubmed/4363956
work_keys_str_mv AT lingwoodclifforda rapidchangesinnucleosidetransportinducedbygrowthinhibitorsstudieswithneoplasticmastcells
AT thomasdbrian rapidchangesinnucleosidetransportinducedbygrowthinhibitorsstudieswithneoplasticmastcells

Ejemplares similares