In vivo recovery of muscle contraction after alpha-bungarotoxin binding

Acetylcholine receptors were inactivated in vivo at the mouse neuromuscular junction using alpha-bungarotoxin (alpha-BTX). It was found that neurally produced muscle contraction recovered within 4-8 days (halftime similar to 3 days). Actinomycin D interfered with this recovery, but did not affect no...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1975
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2109518/
https://www.ncbi.nlm.nih.gov/pubmed/1141378
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collection PubMed
description Acetylcholine receptors were inactivated in vivo at the mouse neuromuscular junction using alpha-bungarotoxin (alpha-BTX). It was found that neurally produced muscle contraction recovered within 4-8 days (halftime similar to 3 days). Actinomycin D interfered with this recovery, but did not affect normal nerve-stimulated muscle contraction. If the response was initially eliminated by [125-I]alpha- BTX and the end plates examined by EM autoradiography, no evidence of mass internalization of bound radioactivity during recovery was seen. The fine structure of the end plates and muscle was unaltered during the post-alpha-BTX recovery period.
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spelling pubmed-21095182008-05-01 In vivo recovery of muscle contraction after alpha-bungarotoxin binding J Cell Biol Articles Acetylcholine receptors were inactivated in vivo at the mouse neuromuscular junction using alpha-bungarotoxin (alpha-BTX). It was found that neurally produced muscle contraction recovered within 4-8 days (halftime similar to 3 days). Actinomycin D interfered with this recovery, but did not affect normal nerve-stimulated muscle contraction. If the response was initially eliminated by [125-I]alpha- BTX and the end plates examined by EM autoradiography, no evidence of mass internalization of bound radioactivity during recovery was seen. The fine structure of the end plates and muscle was unaltered during the post-alpha-BTX recovery period. The Rockefeller University Press 1975-07-01 /pmc/articles/PMC2109518/ /pubmed/1141378 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
In vivo recovery of muscle contraction after alpha-bungarotoxin binding
title In vivo recovery of muscle contraction after alpha-bungarotoxin binding
title_full In vivo recovery of muscle contraction after alpha-bungarotoxin binding
title_fullStr In vivo recovery of muscle contraction after alpha-bungarotoxin binding
title_full_unstemmed In vivo recovery of muscle contraction after alpha-bungarotoxin binding
title_short In vivo recovery of muscle contraction after alpha-bungarotoxin binding
title_sort in vivo recovery of muscle contraction after alpha-bungarotoxin binding
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2109518/
https://www.ncbi.nlm.nih.gov/pubmed/1141378

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