Reinitiation of DNA synthesis in senescent human fibroblasts upon fusion with cells of unlimited growth potential

Postreplicative, "senescent" human fibroblasts were fused to HeLa or to SV-40 transformed human fibroblasts with Sendai virus. DNA synthesis was reinitiated in senescent nuclei in a high proportion of the heterodikaryons. The [3H]thymidine labeling index of senescent fibroblast nuclei in h...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1975
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2109544/
https://www.ncbi.nlm.nih.gov/pubmed/1150745
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description Postreplicative, "senescent" human fibroblasts were fused to HeLa or to SV-40 transformed human fibroblasts with Sendai virus. DNA synthesis was reinitiated in senescent nuclei in a high proportion of the heterodikaryons. The [3H]thymidine labeling index of senescent fibroblast nuclei in heteropolykaryons was a function of the ratio of HeLa to senescent nuclei.
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spelling pubmed-21095442008-05-01 Reinitiation of DNA synthesis in senescent human fibroblasts upon fusion with cells of unlimited growth potential J Cell Biol Articles Postreplicative, "senescent" human fibroblasts were fused to HeLa or to SV-40 transformed human fibroblasts with Sendai virus. DNA synthesis was reinitiated in senescent nuclei in a high proportion of the heterodikaryons. The [3H]thymidine labeling index of senescent fibroblast nuclei in heteropolykaryons was a function of the ratio of HeLa to senescent nuclei. The Rockefeller University Press 1975-03-01 /pmc/articles/PMC2109544/ /pubmed/1150745 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Reinitiation of DNA synthesis in senescent human fibroblasts upon fusion with cells of unlimited growth potential
title Reinitiation of DNA synthesis in senescent human fibroblasts upon fusion with cells of unlimited growth potential
title_full Reinitiation of DNA synthesis in senescent human fibroblasts upon fusion with cells of unlimited growth potential
title_fullStr Reinitiation of DNA synthesis in senescent human fibroblasts upon fusion with cells of unlimited growth potential
title_full_unstemmed Reinitiation of DNA synthesis in senescent human fibroblasts upon fusion with cells of unlimited growth potential
title_short Reinitiation of DNA synthesis in senescent human fibroblasts upon fusion with cells of unlimited growth potential
title_sort reinitiation of dna synthesis in senescent human fibroblasts upon fusion with cells of unlimited growth potential
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2109544/
https://www.ncbi.nlm.nih.gov/pubmed/1150745

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