Inhibition of interferon secretion by vinblastine

The plant alkaloids vinblastine and colchicine are known to arrest cells in mitosis by virtue of their binding to spindle protein. These drugs are also capable of binding to microtubule protein and causing these structures to disaggregate into nonfunctional subunits (1, 2). Microtubular structures a...

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Detalles Bibliográficos
Autores principales: Havell, EA, Vilcek, J
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1975
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2109546/
https://www.ncbi.nlm.nih.gov/pubmed/1150749
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author Havell, EA
Vilcek, J
author_facet Havell, EA
Vilcek, J
author_sort Havell, EA
collection PubMed
description The plant alkaloids vinblastine and colchicine are known to arrest cells in mitosis by virtue of their binding to spindle protein. These drugs are also capable of binding to microtubule protein and causing these structures to disaggregate into nonfunctional subunits (1, 2). Microtubular structures are thought to be involved in the secretory process of a number of proteins including insulin (7), collagen (4), and thyroid hormone (12). In this report we present our findings on the effects of these two drugs on the synthesis and secretion of interferon in a high producing human foreskin fibroblast strain (FS-4) (11).
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spelling pubmed-21095462008-05-01 Inhibition of interferon secretion by vinblastine Havell, EA Vilcek, J J Cell Biol Articles The plant alkaloids vinblastine and colchicine are known to arrest cells in mitosis by virtue of their binding to spindle protein. These drugs are also capable of binding to microtubule protein and causing these structures to disaggregate into nonfunctional subunits (1, 2). Microtubular structures are thought to be involved in the secretory process of a number of proteins including insulin (7), collagen (4), and thyroid hormone (12). In this report we present our findings on the effects of these two drugs on the synthesis and secretion of interferon in a high producing human foreskin fibroblast strain (FS-4) (11). The Rockefeller University Press 1975-03-01 /pmc/articles/PMC2109546/ /pubmed/1150749 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Havell, EA
Vilcek, J
Inhibition of interferon secretion by vinblastine
title Inhibition of interferon secretion by vinblastine
title_full Inhibition of interferon secretion by vinblastine
title_fullStr Inhibition of interferon secretion by vinblastine
title_full_unstemmed Inhibition of interferon secretion by vinblastine
title_short Inhibition of interferon secretion by vinblastine
title_sort inhibition of interferon secretion by vinblastine
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2109546/
https://www.ncbi.nlm.nih.gov/pubmed/1150749
work_keys_str_mv AT havellea inhibitionofinterferonsecretionbyvinblastine
AT vilcekj inhibitionofinterferonsecretionbyvinblastine

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