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Concanavalin A induces microtubule assembly and specific granule discharge in human polymorphonuclear leukocytes
Human neutrophils stimulated by concanavalin A (Con A, 100 microng/ml) contained markedly enhanced numbers of microtubules and discharged peroxidase-negative (specific) but not peroxidase-position (azurophile) granules. Release of lysozyme from specific granules was dose and time dependent, could be...
Formato: | Texto |
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Lenguaje: | English |
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The Rockefeller University Press
1976
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2109658/ https://www.ncbi.nlm.nih.gov/pubmed/1025156 |
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collection | PubMed |
description | Human neutrophils stimulated by concanavalin A (Con A, 100 microng/ml) contained markedly enhanced numbers of microtubules and discharged peroxidase-negative (specific) but not peroxidase-position (azurophile) granules. Release of lysozyme from specific granules was dose and time dependent, could be inhibitied by alpha-methyl-D-mannoside, and enhanced by cytochalasin B. Many microtubules were associated with internalized plasma membrane bearing Con A binding sites. |
format | Text |
id | pubmed-2109658 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1976 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21096582008-05-01 Concanavalin A induces microtubule assembly and specific granule discharge in human polymorphonuclear leukocytes J Cell Biol Articles Human neutrophils stimulated by concanavalin A (Con A, 100 microng/ml) contained markedly enhanced numbers of microtubules and discharged peroxidase-negative (specific) but not peroxidase-position (azurophile) granules. Release of lysozyme from specific granules was dose and time dependent, could be inhibitied by alpha-methyl-D-mannoside, and enhanced by cytochalasin B. Many microtubules were associated with internalized plasma membrane bearing Con A binding sites. The Rockefeller University Press 1976-03-01 /pmc/articles/PMC2109658/ /pubmed/1025156 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Articles Concanavalin A induces microtubule assembly and specific granule discharge in human polymorphonuclear leukocytes |
title | Concanavalin A induces microtubule assembly and specific granule discharge in human polymorphonuclear leukocytes |
title_full | Concanavalin A induces microtubule assembly and specific granule discharge in human polymorphonuclear leukocytes |
title_fullStr | Concanavalin A induces microtubule assembly and specific granule discharge in human polymorphonuclear leukocytes |
title_full_unstemmed | Concanavalin A induces microtubule assembly and specific granule discharge in human polymorphonuclear leukocytes |
title_short | Concanavalin A induces microtubule assembly and specific granule discharge in human polymorphonuclear leukocytes |
title_sort | concanavalin a induces microtubule assembly and specific granule discharge in human polymorphonuclear leukocytes |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2109658/ https://www.ncbi.nlm.nih.gov/pubmed/1025156 |