Concanavalin A induces microtubule assembly and specific granule discharge in human polymorphonuclear leukocytes

Human neutrophils stimulated by concanavalin A (Con A, 100 microng/ml) contained markedly enhanced numbers of microtubules and discharged peroxidase-negative (specific) but not peroxidase-position (azurophile) granules. Release of lysozyme from specific granules was dose and time dependent, could be...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1976
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2109658/
https://www.ncbi.nlm.nih.gov/pubmed/1025156
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collection PubMed
description Human neutrophils stimulated by concanavalin A (Con A, 100 microng/ml) contained markedly enhanced numbers of microtubules and discharged peroxidase-negative (specific) but not peroxidase-position (azurophile) granules. Release of lysozyme from specific granules was dose and time dependent, could be inhibitied by alpha-methyl-D-mannoside, and enhanced by cytochalasin B. Many microtubules were associated with internalized plasma membrane bearing Con A binding sites.
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spelling pubmed-21096582008-05-01 Concanavalin A induces microtubule assembly and specific granule discharge in human polymorphonuclear leukocytes J Cell Biol Articles Human neutrophils stimulated by concanavalin A (Con A, 100 microng/ml) contained markedly enhanced numbers of microtubules and discharged peroxidase-negative (specific) but not peroxidase-position (azurophile) granules. Release of lysozyme from specific granules was dose and time dependent, could be inhibitied by alpha-methyl-D-mannoside, and enhanced by cytochalasin B. Many microtubules were associated with internalized plasma membrane bearing Con A binding sites. The Rockefeller University Press 1976-03-01 /pmc/articles/PMC2109658/ /pubmed/1025156 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Concanavalin A induces microtubule assembly and specific granule discharge in human polymorphonuclear leukocytes
title Concanavalin A induces microtubule assembly and specific granule discharge in human polymorphonuclear leukocytes
title_full Concanavalin A induces microtubule assembly and specific granule discharge in human polymorphonuclear leukocytes
title_fullStr Concanavalin A induces microtubule assembly and specific granule discharge in human polymorphonuclear leukocytes
title_full_unstemmed Concanavalin A induces microtubule assembly and specific granule discharge in human polymorphonuclear leukocytes
title_short Concanavalin A induces microtubule assembly and specific granule discharge in human polymorphonuclear leukocytes
title_sort concanavalin a induces microtubule assembly and specific granule discharge in human polymorphonuclear leukocytes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2109658/
https://www.ncbi.nlm.nih.gov/pubmed/1025156

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