Cargando…

Biological membranes as bilayer couples. III. Compensatory shape changes induced in membranes

We have previously proposed the hypothesis that asymmetric membranes behave like bilayer couples: the two layers of the bilayer membrane can respond differently to a particular perturbation. Such a perturbation, for example, can result in the expansion of one layer relative to the other, thereby pro...

Descripción completa

Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1976
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2109799/
https://www.ncbi.nlm.nih.gov/pubmed/945277
_version_ 1782139401561702400
collection PubMed
description We have previously proposed the hypothesis that asymmetric membranes behave like bilayer couples: the two layers of the bilayer membrane can respond differently to a particular perturbation. Such a perturbation, for example, can result in the expansion of one layer relative to the other, thereby producing a curvature of that membrane. In experiments with erythrocytes and lymphocytes, we now demonstrate that different membrane perturbations which have opposite effects on membrane curvature can compensate and neutralize one another, as expected from the bilayer couple hypothesis. This provides a rational basis, for example, for understanding the effects of amphipathic drugs on a variety of cellular phenomena which involve shape changes of membranes.
format Text
id pubmed-2109799
institution National Center for Biotechnology Information
language English
publishDate 1976
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21097992008-05-01 Biological membranes as bilayer couples. III. Compensatory shape changes induced in membranes J Cell Biol Articles We have previously proposed the hypothesis that asymmetric membranes behave like bilayer couples: the two layers of the bilayer membrane can respond differently to a particular perturbation. Such a perturbation, for example, can result in the expansion of one layer relative to the other, thereby producing a curvature of that membrane. In experiments with erythrocytes and lymphocytes, we now demonstrate that different membrane perturbations which have opposite effects on membrane curvature can compensate and neutralize one another, as expected from the bilayer couple hypothesis. This provides a rational basis, for example, for understanding the effects of amphipathic drugs on a variety of cellular phenomena which involve shape changes of membranes. The Rockefeller University Press 1976-07-01 /pmc/articles/PMC2109799/ /pubmed/945277 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Biological membranes as bilayer couples. III. Compensatory shape changes induced in membranes
title Biological membranes as bilayer couples. III. Compensatory shape changes induced in membranes
title_full Biological membranes as bilayer couples. III. Compensatory shape changes induced in membranes
title_fullStr Biological membranes as bilayer couples. III. Compensatory shape changes induced in membranes
title_full_unstemmed Biological membranes as bilayer couples. III. Compensatory shape changes induced in membranes
title_short Biological membranes as bilayer couples. III. Compensatory shape changes induced in membranes
title_sort biological membranes as bilayer couples. iii. compensatory shape changes induced in membranes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2109799/
https://www.ncbi.nlm.nih.gov/pubmed/945277