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Biological membranes as bilayer couples. III. Compensatory shape changes induced in membranes
We have previously proposed the hypothesis that asymmetric membranes behave like bilayer couples: the two layers of the bilayer membrane can respond differently to a particular perturbation. Such a perturbation, for example, can result in the expansion of one layer relative to the other, thereby pro...
Formato: | Texto |
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Lenguaje: | English |
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The Rockefeller University Press
1976
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2109799/ https://www.ncbi.nlm.nih.gov/pubmed/945277 |
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collection | PubMed |
description | We have previously proposed the hypothesis that asymmetric membranes behave like bilayer couples: the two layers of the bilayer membrane can respond differently to a particular perturbation. Such a perturbation, for example, can result in the expansion of one layer relative to the other, thereby producing a curvature of that membrane. In experiments with erythrocytes and lymphocytes, we now demonstrate that different membrane perturbations which have opposite effects on membrane curvature can compensate and neutralize one another, as expected from the bilayer couple hypothesis. This provides a rational basis, for example, for understanding the effects of amphipathic drugs on a variety of cellular phenomena which involve shape changes of membranes. |
format | Text |
id | pubmed-2109799 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1976 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21097992008-05-01 Biological membranes as bilayer couples. III. Compensatory shape changes induced in membranes J Cell Biol Articles We have previously proposed the hypothesis that asymmetric membranes behave like bilayer couples: the two layers of the bilayer membrane can respond differently to a particular perturbation. Such a perturbation, for example, can result in the expansion of one layer relative to the other, thereby producing a curvature of that membrane. In experiments with erythrocytes and lymphocytes, we now demonstrate that different membrane perturbations which have opposite effects on membrane curvature can compensate and neutralize one another, as expected from the bilayer couple hypothesis. This provides a rational basis, for example, for understanding the effects of amphipathic drugs on a variety of cellular phenomena which involve shape changes of membranes. The Rockefeller University Press 1976-07-01 /pmc/articles/PMC2109799/ /pubmed/945277 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Articles Biological membranes as bilayer couples. III. Compensatory shape changes induced in membranes |
title | Biological membranes as bilayer couples. III. Compensatory shape changes induced in membranes |
title_full | Biological membranes as bilayer couples. III. Compensatory shape changes induced in membranes |
title_fullStr | Biological membranes as bilayer couples. III. Compensatory shape changes induced in membranes |
title_full_unstemmed | Biological membranes as bilayer couples. III. Compensatory shape changes induced in membranes |
title_short | Biological membranes as bilayer couples. III. Compensatory shape changes induced in membranes |
title_sort | biological membranes as bilayer couples. iii. compensatory shape changes induced in membranes |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2109799/ https://www.ncbi.nlm.nih.gov/pubmed/945277 |