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Cytotoxicity for tumor cells of cationic proteins from human neutrophil granules
Cationic proteins purified from human polymorphonuclear leukocyte granules exert a cytotoxic effect on mammalian tumor cells. This effect is time and concentration dependent, is inhibited by the anionic agent heparin, and is enhanced by preheating the cationic proteins. Other strongly basic proteins...
| Formato: | Texto |
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| Lenguaje: | English |
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The Rockefeller University Press
1976
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2109852/ https://www.ncbi.nlm.nih.gov/pubmed/182702 |
| _version_ | 1782139416576262144 |
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| collection | PubMed |
| description | Cationic proteins purified from human polymorphonuclear leukocyte granules exert a cytotoxic effect on mammalian tumor cells. This effect is time and concentration dependent, is inhibited by the anionic agent heparin, and is enhanced by preheating the cationic proteins. Other strongly basic proteins (histone, protamine) also exhibited cytotoxic activity. Myeloperoxidase isolated from human leukocytes is cytotoxic when combined with H2O2 and chloride. Under these conditions, the potency of the myeloperoxidase-mediated system is greater than that of the cationic proteins. |
| format | Text |
| id | pubmed-2109852 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 1976 |
| publisher | The Rockefeller University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-21098522008-05-01 Cytotoxicity for tumor cells of cationic proteins from human neutrophil granules J Cell Biol Articles Cationic proteins purified from human polymorphonuclear leukocyte granules exert a cytotoxic effect on mammalian tumor cells. This effect is time and concentration dependent, is inhibited by the anionic agent heparin, and is enhanced by preheating the cationic proteins. Other strongly basic proteins (histone, protamine) also exhibited cytotoxic activity. Myeloperoxidase isolated from human leukocytes is cytotoxic when combined with H2O2 and chloride. Under these conditions, the potency of the myeloperoxidase-mediated system is greater than that of the cationic proteins. The Rockefeller University Press 1976-09-01 /pmc/articles/PMC2109852/ /pubmed/182702 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
| spellingShingle | Articles Cytotoxicity for tumor cells of cationic proteins from human neutrophil granules |
| title | Cytotoxicity for tumor cells of cationic proteins from human neutrophil granules |
| title_full | Cytotoxicity for tumor cells of cationic proteins from human neutrophil granules |
| title_fullStr | Cytotoxicity for tumor cells of cationic proteins from human neutrophil granules |
| title_full_unstemmed | Cytotoxicity for tumor cells of cationic proteins from human neutrophil granules |
| title_short | Cytotoxicity for tumor cells of cationic proteins from human neutrophil granules |
| title_sort | cytotoxicity for tumor cells of cationic proteins from human neutrophil granules |
| topic | Articles |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2109852/ https://www.ncbi.nlm.nih.gov/pubmed/182702 |