Activation of the rabbit polymorphonuclear leukocyte membrane "Na+, K+"- ATPase by chemotactic factor

Addition of the synthetic chemotactic factor, formyl-methionyl-leucyl- phenylala-nine (F-Met-Leu-Phe) to medium containing magnesium, sodium, and potassium results in a doubling of the "Na+, K+"-ATPase activity of the plasma membrane fraction from polymophonuclear leukocytes (PMN). This ac...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1978
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Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2110048/
https://www.ncbi.nlm.nih.gov/pubmed/148465
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collection PubMed
description Addition of the synthetic chemotactic factor, formyl-methionyl-leucyl- phenylala-nine (F-Met-Leu-Phe) to medium containing magnesium, sodium, and potassium results in a doubling of the "Na+, K+"-ATPase activity of the plasma membrane fraction from polymophonuclear leukocytes (PMN). This activation is sensitive to ouabain inhibition and is dose dependent, maximal activity occuring at 10(-9)MF-Met-Leu-Phe. Equivalent activation was observed with the nonformylated derivative Met-Leu-Phe at 10(-9)M. The dipeptide, carbobenzoxy- methionylphenylalanine, which acts as an antagonist for F-Met-Leu-Phe, prevents the stimulation of the "Na+, K+"-ATPase by F-Met-Leu-Phe.
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spelling pubmed-21100482008-05-01 Activation of the rabbit polymorphonuclear leukocyte membrane "Na+, K+"- ATPase by chemotactic factor J Cell Biol Articles Addition of the synthetic chemotactic factor, formyl-methionyl-leucyl- phenylala-nine (F-Met-Leu-Phe) to medium containing magnesium, sodium, and potassium results in a doubling of the "Na+, K+"-ATPase activity of the plasma membrane fraction from polymophonuclear leukocytes (PMN). This activation is sensitive to ouabain inhibition and is dose dependent, maximal activity occuring at 10(-9)MF-Met-Leu-Phe. Equivalent activation was observed with the nonformylated derivative Met-Leu-Phe at 10(-9)M. The dipeptide, carbobenzoxy- methionylphenylalanine, which acts as an antagonist for F-Met-Leu-Phe, prevents the stimulation of the "Na+, K+"-ATPase by F-Met-Leu-Phe. The Rockefeller University Press 1978-05-01 /pmc/articles/PMC2110048/ /pubmed/148465 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Activation of the rabbit polymorphonuclear leukocyte membrane "Na+, K+"- ATPase by chemotactic factor
title Activation of the rabbit polymorphonuclear leukocyte membrane "Na+, K+"- ATPase by chemotactic factor
title_full Activation of the rabbit polymorphonuclear leukocyte membrane "Na+, K+"- ATPase by chemotactic factor
title_fullStr Activation of the rabbit polymorphonuclear leukocyte membrane "Na+, K+"- ATPase by chemotactic factor
title_full_unstemmed Activation of the rabbit polymorphonuclear leukocyte membrane "Na+, K+"- ATPase by chemotactic factor
title_short Activation of the rabbit polymorphonuclear leukocyte membrane "Na+, K+"- ATPase by chemotactic factor
title_sort activation of the rabbit polymorphonuclear leukocyte membrane "na+, k+"- atpase by chemotactic factor
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2110048/
https://www.ncbi.nlm.nih.gov/pubmed/148465

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