A mode of formation of tubular myelin from lamellar bodies in the lung

A mechanism is suggested by which the membranes of lamellar bodies are converted to tubular myelin (TM) in the lung. It is argued that a simple corrugation of the membranous sheets can produce the TM formation. Such corrugation would occur in response to simple stresses acting on the lamellar body m...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1977
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2110109/
https://www.ncbi.nlm.nih.gov/pubmed/903368
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collection PubMed
description A mechanism is suggested by which the membranes of lamellar bodies are converted to tubular myelin (TM) in the lung. It is argued that a simple corrugation of the membranous sheets can produce the TM formation. Such corrugation would occur in response to simple stresses acting on the lamellar body membranes. The intersections of the tubular figures are formed by fusion of adjacent corners in the corrugations. This results in a more stable hydrophobic bonding of phospholipid molecules. Strong supportive evidence for the mechanism is given by electron micrographs of TM formations.
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spelling pubmed-21101092008-05-01 A mode of formation of tubular myelin from lamellar bodies in the lung J Cell Biol Articles A mechanism is suggested by which the membranes of lamellar bodies are converted to tubular myelin (TM) in the lung. It is argued that a simple corrugation of the membranous sheets can produce the TM formation. Such corrugation would occur in response to simple stresses acting on the lamellar body membranes. The intersections of the tubular figures are formed by fusion of adjacent corners in the corrugations. This results in a more stable hydrophobic bonding of phospholipid molecules. Strong supportive evidence for the mechanism is given by electron micrographs of TM formations. The Rockefeller University Press 1977-09-01 /pmc/articles/PMC2110109/ /pubmed/903368 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
A mode of formation of tubular myelin from lamellar bodies in the lung
title A mode of formation of tubular myelin from lamellar bodies in the lung
title_full A mode of formation of tubular myelin from lamellar bodies in the lung
title_fullStr A mode of formation of tubular myelin from lamellar bodies in the lung
title_full_unstemmed A mode of formation of tubular myelin from lamellar bodies in the lung
title_short A mode of formation of tubular myelin from lamellar bodies in the lung
title_sort mode of formation of tubular myelin from lamellar bodies in the lung
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2110109/
https://www.ncbi.nlm.nih.gov/pubmed/903368

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