Temporal organization of replication in DNA fibers of mammalian cells

The extent of coordinate control over the multiple initiation events in DNA replication has been investigated in three mammalian cell lines by DNA fiber autoradiography. Quantitative estimates have been obtained of the degree of synchrony among initiations occurring on stretches of DNA. Synchrony de...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1979
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2110389/
https://www.ncbi.nlm.nih.gov/pubmed/457781
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description The extent of coordinate control over the multiple initiation events in DNA replication has been investigated in three mammalian cell lines by DNA fiber autoradiography. Quantitative estimates have been obtained of the degree of synchrony among initiations occurring on stretches of DNA. Synchrony decreases markedly with increasing distance between initiation sites in MDBK (bovine) and L929 (mouse) cells, but only slightly in muntjac cells. Possible control mechanisms for the initiation process are discussed.
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spelling pubmed-21103892008-05-01 Temporal organization of replication in DNA fibers of mammalian cells J Cell Biol Articles The extent of coordinate control over the multiple initiation events in DNA replication has been investigated in three mammalian cell lines by DNA fiber autoradiography. Quantitative estimates have been obtained of the degree of synchrony among initiations occurring on stretches of DNA. Synchrony decreases markedly with increasing distance between initiation sites in MDBK (bovine) and L929 (mouse) cells, but only slightly in muntjac cells. Possible control mechanisms for the initiation process are discussed. The Rockefeller University Press 1979-06-01 /pmc/articles/PMC2110389/ /pubmed/457781 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Temporal organization of replication in DNA fibers of mammalian cells
title Temporal organization of replication in DNA fibers of mammalian cells
title_full Temporal organization of replication in DNA fibers of mammalian cells
title_fullStr Temporal organization of replication in DNA fibers of mammalian cells
title_full_unstemmed Temporal organization of replication in DNA fibers of mammalian cells
title_short Temporal organization of replication in DNA fibers of mammalian cells
title_sort temporal organization of replication in dna fibers of mammalian cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2110389/
https://www.ncbi.nlm.nih.gov/pubmed/457781

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