Developmental program of murine erythroleukemia cells. Effect of the inhibition of protein synthesis

The relationship between protein synthesis and commitment to terminal erythroid differentiation by dimethylsulfoxide-treated murine erythroleukemia (MEL) cells has been studied. Treatment with cycloheximide blocks the commitment of MEL cells. The effects of cycloheximide are completely reversible, h...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1979
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2110478/
https://www.ncbi.nlm.nih.gov/pubmed/292644
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collection PubMed
description The relationship between protein synthesis and commitment to terminal erythroid differentiation by dimethylsulfoxide-treated murine erythroleukemia (MEL) cells has been studied. Treatment with cycloheximide blocks the commitment of MEL cells. The effects of cycloheximide are completely reversible, however. Treatment of MEL cells before commitment delays commitment for a period of time equal to the length of inhibitor treatment. Puromycin exerts a similar effect on the commitment of MEL cells. These results indicate that there is a continuous requirement for protein synthesis before the commitment event.
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spelling pubmed-21104782008-05-01 Developmental program of murine erythroleukemia cells. Effect of the inhibition of protein synthesis J Cell Biol Articles The relationship between protein synthesis and commitment to terminal erythroid differentiation by dimethylsulfoxide-treated murine erythroleukemia (MEL) cells has been studied. Treatment with cycloheximide blocks the commitment of MEL cells. The effects of cycloheximide are completely reversible, however. Treatment of MEL cells before commitment delays commitment for a period of time equal to the length of inhibitor treatment. Puromycin exerts a similar effect on the commitment of MEL cells. These results indicate that there is a continuous requirement for protein synthesis before the commitment event. The Rockefeller University Press 1979-09-01 /pmc/articles/PMC2110478/ /pubmed/292644 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Developmental program of murine erythroleukemia cells. Effect of the inhibition of protein synthesis
title Developmental program of murine erythroleukemia cells. Effect of the inhibition of protein synthesis
title_full Developmental program of murine erythroleukemia cells. Effect of the inhibition of protein synthesis
title_fullStr Developmental program of murine erythroleukemia cells. Effect of the inhibition of protein synthesis
title_full_unstemmed Developmental program of murine erythroleukemia cells. Effect of the inhibition of protein synthesis
title_short Developmental program of murine erythroleukemia cells. Effect of the inhibition of protein synthesis
title_sort developmental program of murine erythroleukemia cells. effect of the inhibition of protein synthesis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2110478/
https://www.ncbi.nlm.nih.gov/pubmed/292644

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