Intercellular adhesion as a function of the cell cycle traverse

Intercellular adhesion is assumed to play an important role in a multitude of biological phenomena governing cellular behavior. The rate of intercellular adhesion as a function of the cell cycle traverse has been investigated using, in the monolayer assay, synchronized Chinese Hamster Ovary-K1 cells. Results obtained demonstrate that cells in G1 adhere to G1 cells at twice the rate that S cells adhere to each other. G1 cells adhere to S cells at an intermediate rate. The additive adhesiveness seen in G1 is abolished by brief trypsinization, suggesting that in G1 a qualitative or quantitative change occurs with respect to the presence or exposure of components involved in intercellular adhesion.