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Morphological changes in tight junctions of Necturus maculosus proximal tubules undergoing saline diuresis
Tight junctions between epithelial cells are believed to control the paracellular diffusion of substances across epithelia. Epithelia in which tight junctions are poorly developed display a higher paracellular electrical conductance, while those with extensive tight junctions show lower conductance...
Formato: | Texto |
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Lenguaje: | English |
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The Rockefeller University Press
1976
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2110974/ https://www.ncbi.nlm.nih.gov/pubmed/1254651 |
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collection | PubMed |
description | Tight junctions between epithelial cells are believed to control the paracellular diffusion of substances across epithelia. Epithelia in which tight junctions are poorly developed display a higher paracellular electrical conductance, while those with extensive tight junctions show lower conductance values. We described here a particular epithelium, that of the proximal tubules of the Necturus kidney, in which the development of the tight junctions varies in parallel with a change of paracellular electrical conductance. In control conditions, tight junctions between epithelial cells of the proximal tubules are more developed than in tubules undergoing saline diuresis, a situation which increases the conductance across the paracellular shunt pathway. |
format | Text |
id | pubmed-2110974 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1976 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21109742008-05-01 Morphological changes in tight junctions of Necturus maculosus proximal tubules undergoing saline diuresis J Cell Biol Articles Tight junctions between epithelial cells are believed to control the paracellular diffusion of substances across epithelia. Epithelia in which tight junctions are poorly developed display a higher paracellular electrical conductance, while those with extensive tight junctions show lower conductance values. We described here a particular epithelium, that of the proximal tubules of the Necturus kidney, in which the development of the tight junctions varies in parallel with a change of paracellular electrical conductance. In control conditions, tight junctions between epithelial cells of the proximal tubules are more developed than in tubules undergoing saline diuresis, a situation which increases the conductance across the paracellular shunt pathway. The Rockefeller University Press 1976-04-01 /pmc/articles/PMC2110974/ /pubmed/1254651 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Articles Morphological changes in tight junctions of Necturus maculosus proximal tubules undergoing saline diuresis |
title | Morphological changes in tight junctions of Necturus maculosus proximal tubules undergoing saline diuresis |
title_full | Morphological changes in tight junctions of Necturus maculosus proximal tubules undergoing saline diuresis |
title_fullStr | Morphological changes in tight junctions of Necturus maculosus proximal tubules undergoing saline diuresis |
title_full_unstemmed | Morphological changes in tight junctions of Necturus maculosus proximal tubules undergoing saline diuresis |
title_short | Morphological changes in tight junctions of Necturus maculosus proximal tubules undergoing saline diuresis |
title_sort | morphological changes in tight junctions of necturus maculosus proximal tubules undergoing saline diuresis |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2110974/ https://www.ncbi.nlm.nih.gov/pubmed/1254651 |