Carbamycholine prevents giant granule-formation in cultured fibroblasts from beige (Chediak-Higashi) mice

Primary embryonic fibroblasts isolated from beige (Chediak-Higashi) mice develop pathognomonic giant granules in vitro. Inclusion in the culture medium of carbamylcholine (carbachol) or phorbol myristate acetate (PMA) results in the generation of morphologically normally granules. Chediak-Higashi fi...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1976
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2110978/
https://www.ncbi.nlm.nih.gov/pubmed/1254644
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collection PubMed
description Primary embryonic fibroblasts isolated from beige (Chediak-Higashi) mice develop pathognomonic giant granules in vitro. Inclusion in the culture medium of carbamylcholine (carbachol) or phorbol myristate acetate (PMA) results in the generation of morphologically normally granules. Chediak-Higashi fibroblasts are highly susceptible to shape changes induced by colchicine. This abnormal property is also corrected by carbachol and PMA.
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spelling pubmed-21109782008-05-01 Carbamycholine prevents giant granule-formation in cultured fibroblasts from beige (Chediak-Higashi) mice J Cell Biol Articles Primary embryonic fibroblasts isolated from beige (Chediak-Higashi) mice develop pathognomonic giant granules in vitro. Inclusion in the culture medium of carbamylcholine (carbachol) or phorbol myristate acetate (PMA) results in the generation of morphologically normally granules. Chediak-Higashi fibroblasts are highly susceptible to shape changes induced by colchicine. This abnormal property is also corrected by carbachol and PMA. The Rockefeller University Press 1976-04-01 /pmc/articles/PMC2110978/ /pubmed/1254644 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Carbamycholine prevents giant granule-formation in cultured fibroblasts from beige (Chediak-Higashi) mice
title Carbamycholine prevents giant granule-formation in cultured fibroblasts from beige (Chediak-Higashi) mice
title_full Carbamycholine prevents giant granule-formation in cultured fibroblasts from beige (Chediak-Higashi) mice
title_fullStr Carbamycholine prevents giant granule-formation in cultured fibroblasts from beige (Chediak-Higashi) mice
title_full_unstemmed Carbamycholine prevents giant granule-formation in cultured fibroblasts from beige (Chediak-Higashi) mice
title_short Carbamycholine prevents giant granule-formation in cultured fibroblasts from beige (Chediak-Higashi) mice
title_sort carbamycholine prevents giant granule-formation in cultured fibroblasts from beige (chediak-higashi) mice
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2110978/
https://www.ncbi.nlm.nih.gov/pubmed/1254644

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