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Differential binding of methyl benzimidazol-2-yl carbamate to fungal tubulin as a mechanism of resistance to this antimitotic agent in mutant strains of Aspergillus nidulans
The antimitotic compound methyl benzimidazol-2-yl carbamate (MBC) formed a complex in vitro with a protein present in mycelial extracts of fungi. The binding protein of Aspergillus nidulans showed a set of properties which is unique for tubulin. Binding occurred rapidly at 4 degrees C and was compet...
| Formato: | Texto |
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| Lenguaje: | English |
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The Rockefeller University Press
1977
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2110979/ https://www.ncbi.nlm.nih.gov/pubmed/12184 |