Cargando…
Cell polarity: an examination of its behavioral expression and its consequences for polymorphonuclear leukocyte chemotaxis
Locomoting polymorphonuclear leukocytes (PMNs) exhibit a morphological polarity. We demonstrate that they also exhibit a behavioral polarity in their responsiveness to chemotactic factor stimulation. This is demonstrated by (a) the pattern of their locomotion in a homogeneous concentration of chemot...
Formato: | Texto |
---|---|
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1981
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2111809/ https://www.ncbi.nlm.nih.gov/pubmed/7251666 |
_version_ | 1782139810648948736 |
---|---|
collection | PubMed |
description | Locomoting polymorphonuclear leukocytes (PMNs) exhibit a morphological polarity. We demonstrate that they also exhibit a behavioral polarity in their responsiveness to chemotactic factor stimulation. This is demonstrated by (a) the pattern of their locomotion in a homogeneous concentration of chemotactic factors, (b) their responses to increases in the homogeneous concentration of chemotactic factors, and (c) their responses to changes in the direction of a chemotactic gradient. The behavioral polarity is not a function of the rate of locomotion of the particular stimulant used to orient the cells, but may reflect an asymmetric distribution of chemotactic receptors or the motile machinery. The polar behavior affects the chemotactic ability of PMNs. The data are discussed in relation to possible mechanisms of sensing a chemotactic gradient. |
format | Text |
id | pubmed-2111809 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1981 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21118092008-05-01 Cell polarity: an examination of its behavioral expression and its consequences for polymorphonuclear leukocyte chemotaxis J Cell Biol Articles Locomoting polymorphonuclear leukocytes (PMNs) exhibit a morphological polarity. We demonstrate that they also exhibit a behavioral polarity in their responsiveness to chemotactic factor stimulation. This is demonstrated by (a) the pattern of their locomotion in a homogeneous concentration of chemotactic factors, (b) their responses to increases in the homogeneous concentration of chemotactic factors, and (c) their responses to changes in the direction of a chemotactic gradient. The behavioral polarity is not a function of the rate of locomotion of the particular stimulant used to orient the cells, but may reflect an asymmetric distribution of chemotactic receptors or the motile machinery. The polar behavior affects the chemotactic ability of PMNs. The data are discussed in relation to possible mechanisms of sensing a chemotactic gradient. The Rockefeller University Press 1981-06-01 /pmc/articles/PMC2111809/ /pubmed/7251666 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Articles Cell polarity: an examination of its behavioral expression and its consequences for polymorphonuclear leukocyte chemotaxis |
title | Cell polarity: an examination of its behavioral expression and its consequences for polymorphonuclear leukocyte chemotaxis |
title_full | Cell polarity: an examination of its behavioral expression and its consequences for polymorphonuclear leukocyte chemotaxis |
title_fullStr | Cell polarity: an examination of its behavioral expression and its consequences for polymorphonuclear leukocyte chemotaxis |
title_full_unstemmed | Cell polarity: an examination of its behavioral expression and its consequences for polymorphonuclear leukocyte chemotaxis |
title_short | Cell polarity: an examination of its behavioral expression and its consequences for polymorphonuclear leukocyte chemotaxis |
title_sort | cell polarity: an examination of its behavioral expression and its consequences for polymorphonuclear leukocyte chemotaxis |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2111809/ https://www.ncbi.nlm.nih.gov/pubmed/7251666 |