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Cytoplasmic actin in postsynaptic structures at the neuromuscular junction
We used an antibody prepared against Aplysia (mollusc) body-wall actin that specifically reacts with certain forms of cytoplasmic actin in mammalian cells to probe for the presence of actin at the neuromuscular junction. Immunocytochemical studies showed that actin or an actinlike molecule is concen...
Formato: | Texto |
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Lenguaje: | English |
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The Rockefeller University Press
1981
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2111917/ https://www.ncbi.nlm.nih.gov/pubmed/7026578 |
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collection | PubMed |
description | We used an antibody prepared against Aplysia (mollusc) body-wall actin that specifically reacts with certain forms of cytoplasmic actin in mammalian cells to probe for the presence of actin at the neuromuscular junction. Immunocytochemical studies showed that actin or an actinlike molecule is concentrated at neuromuscular junctions of normal and denervated adult rat muscle fibers. Actin is present at the neuromuscular junctions of fibers of developing diaphragm muscles as early as embryonic day 18, well before postsynaptic folds are formed. These results suggest that cytoplasmic actin may play a role in the clustering or stabilization of acetylcholine receptors at the neuromuscular junction. |
format | Text |
id | pubmed-2111917 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1981 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21119172008-05-01 Cytoplasmic actin in postsynaptic structures at the neuromuscular junction J Cell Biol Articles We used an antibody prepared against Aplysia (mollusc) body-wall actin that specifically reacts with certain forms of cytoplasmic actin in mammalian cells to probe for the presence of actin at the neuromuscular junction. Immunocytochemical studies showed that actin or an actinlike molecule is concentrated at neuromuscular junctions of normal and denervated adult rat muscle fibers. Actin is present at the neuromuscular junctions of fibers of developing diaphragm muscles as early as embryonic day 18, well before postsynaptic folds are formed. These results suggest that cytoplasmic actin may play a role in the clustering or stabilization of acetylcholine receptors at the neuromuscular junction. The Rockefeller University Press 1981-09-01 /pmc/articles/PMC2111917/ /pubmed/7026578 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Articles Cytoplasmic actin in postsynaptic structures at the neuromuscular junction |
title | Cytoplasmic actin in postsynaptic structures at the neuromuscular junction |
title_full | Cytoplasmic actin in postsynaptic structures at the neuromuscular junction |
title_fullStr | Cytoplasmic actin in postsynaptic structures at the neuromuscular junction |
title_full_unstemmed | Cytoplasmic actin in postsynaptic structures at the neuromuscular junction |
title_short | Cytoplasmic actin in postsynaptic structures at the neuromuscular junction |
title_sort | cytoplasmic actin in postsynaptic structures at the neuromuscular junction |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2111917/ https://www.ncbi.nlm.nih.gov/pubmed/7026578 |