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Cytoskeletal organization at the postsynaptic complex
Postsynaptic densities and the adjacent cytoskeleton were examined in deep-etched, unfixed slices of guinea pig anteroventral cochlear nucleus. The postsynaptic density seen in conventional thin sections corresponds to a meshwork of 4-nm filaments associated with intramembrane particles at the posts...
Formato: | Texto |
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Lenguaje: | English |
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The Rockefeller University Press
1981
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2111925/ https://www.ncbi.nlm.nih.gov/pubmed/7197681 |
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collection | PubMed |
description | Postsynaptic densities and the adjacent cytoskeleton were examined in deep-etched, unfixed slices of guinea pig anteroventral cochlear nucleus. The postsynaptic density seen in conventional thin sections corresponds to a meshwork of 4-nm filaments associated with intramembrane particles at the postsynaptic active zone of inhibitory as well as excitatory synapses. These filaments intermesh with a lattice of 8- to 9-nm microfilaments, tentatively identified as F- actin, that is concentrated under the postsynaptic density. We postulate that the meshwork of 4-nm filaments anchors receptors to the adjacent microfilament lattice; this extended postsynaptic complex may limit the mobility of receptors and help maintain the curvature of the postsynaptic membrane. |
format | Text |
id | pubmed-2111925 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1981 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21119252008-05-01 Cytoskeletal organization at the postsynaptic complex J Cell Biol Articles Postsynaptic densities and the adjacent cytoskeleton were examined in deep-etched, unfixed slices of guinea pig anteroventral cochlear nucleus. The postsynaptic density seen in conventional thin sections corresponds to a meshwork of 4-nm filaments associated with intramembrane particles at the postsynaptic active zone of inhibitory as well as excitatory synapses. These filaments intermesh with a lattice of 8- to 9-nm microfilaments, tentatively identified as F- actin, that is concentrated under the postsynaptic density. We postulate that the meshwork of 4-nm filaments anchors receptors to the adjacent microfilament lattice; this extended postsynaptic complex may limit the mobility of receptors and help maintain the curvature of the postsynaptic membrane. The Rockefeller University Press 1981-10-01 /pmc/articles/PMC2111925/ /pubmed/7197681 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Articles Cytoskeletal organization at the postsynaptic complex |
title | Cytoskeletal organization at the postsynaptic complex |
title_full | Cytoskeletal organization at the postsynaptic complex |
title_fullStr | Cytoskeletal organization at the postsynaptic complex |
title_full_unstemmed | Cytoskeletal organization at the postsynaptic complex |
title_short | Cytoskeletal organization at the postsynaptic complex |
title_sort | cytoskeletal organization at the postsynaptic complex |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2111925/ https://www.ncbi.nlm.nih.gov/pubmed/7197681 |