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Induction of polarity in mouse 8-cell blastomeres: specificity, geometry, and stability

We studied the cellular mechanisms underlying the induction of polarity in individual blastomeres of the 8-cell mouse embryo. The ability to induce polarity is lacking in the membranes of unfertilized and newly fertilized mouse eggs, then develops during the 2-cell stage, and is present in membranes...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1981
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2111944/
https://www.ncbi.nlm.nih.gov/pubmed/7298724
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description We studied the cellular mechanisms underlying the induction of polarity in individual blastomeres of the 8-cell mouse embryo. The ability to induce polarity is lacking in the membranes of unfertilized and newly fertilized mouse eggs, then develops during the 2-cell stage, and is present in membranes of cells from 4-, 8-, and 16-cell stages. The axis of polarity takes 3-5 h to become established and thereafter appears to be stable. Multiple cell contacts affect the orientation of the axis of polarity, and no polarity develops in cells which are totally surrounded. Polarized cells show evidence of an limited capacity for slight adjustments in their position relative to other cells. The implications of these results for the mechanisms by which a blastocyst is generated are discussed briefly.
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spelling pubmed-21119442008-05-01 Induction of polarity in mouse 8-cell blastomeres: specificity, geometry, and stability J Cell Biol Articles We studied the cellular mechanisms underlying the induction of polarity in individual blastomeres of the 8-cell mouse embryo. The ability to induce polarity is lacking in the membranes of unfertilized and newly fertilized mouse eggs, then develops during the 2-cell stage, and is present in membranes of cells from 4-, 8-, and 16-cell stages. The axis of polarity takes 3-5 h to become established and thereafter appears to be stable. Multiple cell contacts affect the orientation of the axis of polarity, and no polarity develops in cells which are totally surrounded. Polarized cells show evidence of an limited capacity for slight adjustments in their position relative to other cells. The implications of these results for the mechanisms by which a blastocyst is generated are discussed briefly. The Rockefeller University Press 1981-10-01 /pmc/articles/PMC2111944/ /pubmed/7298724 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Induction of polarity in mouse 8-cell blastomeres: specificity, geometry, and stability
title Induction of polarity in mouse 8-cell blastomeres: specificity, geometry, and stability
title_full Induction of polarity in mouse 8-cell blastomeres: specificity, geometry, and stability
title_fullStr Induction of polarity in mouse 8-cell blastomeres: specificity, geometry, and stability
title_full_unstemmed Induction of polarity in mouse 8-cell blastomeres: specificity, geometry, and stability
title_short Induction of polarity in mouse 8-cell blastomeres: specificity, geometry, and stability
title_sort induction of polarity in mouse 8-cell blastomeres: specificity, geometry, and stability
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2111944/
https://www.ncbi.nlm.nih.gov/pubmed/7298724