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Role of osmotic forces in exocytosis: studies of ADH-induced fusion in toad urinary bladder

Antidiuretic hormone (ADH) treatment of toad urinary bladder activates an exocytotic-like process by which intramembrane particle aggregates are transferred from membranes of elongated cytoplasmic tubules to the luminal-facing plasma membrane. We find that the number of these ADH- induced fusion eve...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1981
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2111984/
https://www.ncbi.nlm.nih.gov/pubmed/6796595
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description Antidiuretic hormone (ADH) treatment of toad urinary bladder activates an exocytotic-like process by which intramembrane particle aggregates are transferred from membranes of elongated cytoplasmic tubules to the luminal-facing plasma membrane. We find that the number of these ADH- induced fusion events, and the number of aggregates appearing in the luminal membrane, are reduced when the luminal bathing medium is made hyperosmotic. As an apparent consequence of the inhibition of their fusion with the luminal membrane, the elongated cytoplasmic tubules become enormously swollen into large, rounded vesicles. These results are consistent with the view that osmotic forces are essential to the basic mechanism of exocytosis.
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spelling pubmed-21119842008-05-01 Role of osmotic forces in exocytosis: studies of ADH-induced fusion in toad urinary bladder J Cell Biol Articles Antidiuretic hormone (ADH) treatment of toad urinary bladder activates an exocytotic-like process by which intramembrane particle aggregates are transferred from membranes of elongated cytoplasmic tubules to the luminal-facing plasma membrane. We find that the number of these ADH- induced fusion events, and the number of aggregates appearing in the luminal membrane, are reduced when the luminal bathing medium is made hyperosmotic. As an apparent consequence of the inhibition of their fusion with the luminal membrane, the elongated cytoplasmic tubules become enormously swollen into large, rounded vesicles. These results are consistent with the view that osmotic forces are essential to the basic mechanism of exocytosis. The Rockefeller University Press 1981-11-01 /pmc/articles/PMC2111984/ /pubmed/6796595 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Role of osmotic forces in exocytosis: studies of ADH-induced fusion in toad urinary bladder
title Role of osmotic forces in exocytosis: studies of ADH-induced fusion in toad urinary bladder
title_full Role of osmotic forces in exocytosis: studies of ADH-induced fusion in toad urinary bladder
title_fullStr Role of osmotic forces in exocytosis: studies of ADH-induced fusion in toad urinary bladder
title_full_unstemmed Role of osmotic forces in exocytosis: studies of ADH-induced fusion in toad urinary bladder
title_short Role of osmotic forces in exocytosis: studies of ADH-induced fusion in toad urinary bladder
title_sort role of osmotic forces in exocytosis: studies of adh-induced fusion in toad urinary bladder
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2111984/
https://www.ncbi.nlm.nih.gov/pubmed/6796595