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Glucose removal from N-linked oligosaccharides is required for efficient maturation of certain secretory glycoproteins from the rough endoplasmic reticulum to the Golgi complex
1- Deoxynojirimycin is a specific inhibitor of glucosidases I and II, the first enzymes that process N-linked oligosaccharides after their transfer to polypeptides in the rough endoplasmic reticulum. In a pulse- chase experiment, 1- deoxynojirimycin greatly reduced the rate of secretion of alpha 1-a...
| Formato: | Texto |
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| Lenguaje: | English |
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The Rockefeller University Press
1984
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2113174/ https://www.ncbi.nlm.nih.gov/pubmed/6233287 |