The eucaryotic aminoacyl-tRNA synthetase complex: suggestions for its structure and function

Aminoacyl-tRNA synthetases from eucaryotic cells generally are isolated as high molecular weight complexes comprised of multiple synthetase activities, and often containing other components as well. A model is proposed for the synthetase complex in which hydrophobic extensions on the proteins serve...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1984
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2113280/
https://www.ncbi.nlm.nih.gov/pubmed/6746733
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collection PubMed
description Aminoacyl-tRNA synthetases from eucaryotic cells generally are isolated as high molecular weight complexes comprised of multiple synthetase activities, and often containing other components as well. A model is proposed for the synthetase complex in which hydrophobic extensions on the proteins serve to maintain them in their high molecular weight form, but are not needed for catalytic activity. The structural similarity of these enzymes to certain membrane-bound proteins, and its implications for synthetase localization and function in vivo, are discussed.
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spelling pubmed-21132802008-05-01 The eucaryotic aminoacyl-tRNA synthetase complex: suggestions for its structure and function J Cell Biol Articles Aminoacyl-tRNA synthetases from eucaryotic cells generally are isolated as high molecular weight complexes comprised of multiple synthetase activities, and often containing other components as well. A model is proposed for the synthetase complex in which hydrophobic extensions on the proteins serve to maintain them in their high molecular weight form, but are not needed for catalytic activity. The structural similarity of these enzymes to certain membrane-bound proteins, and its implications for synthetase localization and function in vivo, are discussed. The Rockefeller University Press 1984-08-01 /pmc/articles/PMC2113280/ /pubmed/6746733 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
The eucaryotic aminoacyl-tRNA synthetase complex: suggestions for its structure and function
title The eucaryotic aminoacyl-tRNA synthetase complex: suggestions for its structure and function
title_full The eucaryotic aminoacyl-tRNA synthetase complex: suggestions for its structure and function
title_fullStr The eucaryotic aminoacyl-tRNA synthetase complex: suggestions for its structure and function
title_full_unstemmed The eucaryotic aminoacyl-tRNA synthetase complex: suggestions for its structure and function
title_short The eucaryotic aminoacyl-tRNA synthetase complex: suggestions for its structure and function
title_sort eucaryotic aminoacyl-trna synthetase complex: suggestions for its structure and function
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2113280/
https://www.ncbi.nlm.nih.gov/pubmed/6746733

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