Lysosomal accumulation of the hormone-receptor complex during receptor- mediated endocytosis of human choriogonadotropin

The experiments presented herein were designed to determine the fate of the human choriogonadotropin (hCG) receptor during endocytosis of the receptor-bound hCG. Using several biochemical approaches, it is shown that the receptor is internalized together with the hormone into endocytic vesicles and...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1984
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2113298/
https://www.ncbi.nlm.nih.gov/pubmed/6090468
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collection PubMed
description The experiments presented herein were designed to determine the fate of the human choriogonadotropin (hCG) receptor during endocytosis of the receptor-bound hCG. Using several biochemical approaches, it is shown that the receptor is internalized together with the hormone into endocytic vesicles and transferred to lysosomes without ligand dissociation. Once delivered to the lysosomes, the hCG-receptor complex dissociates, and the free hormone is degraded. This pathway appears to prevent receptor recycling and probably promotes receptor degradation.
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spelling pubmed-21132982008-05-01 Lysosomal accumulation of the hormone-receptor complex during receptor- mediated endocytosis of human choriogonadotropin J Cell Biol Articles The experiments presented herein were designed to determine the fate of the human choriogonadotropin (hCG) receptor during endocytosis of the receptor-bound hCG. Using several biochemical approaches, it is shown that the receptor is internalized together with the hormone into endocytic vesicles and transferred to lysosomes without ligand dissociation. Once delivered to the lysosomes, the hCG-receptor complex dissociates, and the free hormone is degraded. This pathway appears to prevent receptor recycling and probably promotes receptor degradation. The Rockefeller University Press 1984-10-01 /pmc/articles/PMC2113298/ /pubmed/6090468 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Lysosomal accumulation of the hormone-receptor complex during receptor- mediated endocytosis of human choriogonadotropin
title Lysosomal accumulation of the hormone-receptor complex during receptor- mediated endocytosis of human choriogonadotropin
title_full Lysosomal accumulation of the hormone-receptor complex during receptor- mediated endocytosis of human choriogonadotropin
title_fullStr Lysosomal accumulation of the hormone-receptor complex during receptor- mediated endocytosis of human choriogonadotropin
title_full_unstemmed Lysosomal accumulation of the hormone-receptor complex during receptor- mediated endocytosis of human choriogonadotropin
title_short Lysosomal accumulation of the hormone-receptor complex during receptor- mediated endocytosis of human choriogonadotropin
title_sort lysosomal accumulation of the hormone-receptor complex during receptor- mediated endocytosis of human choriogonadotropin
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2113298/
https://www.ncbi.nlm.nih.gov/pubmed/6090468

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