Identification of a 70,000-D protein in lens membrane junctional domains

A 70,000-D membrane protein (MP70), which is restricted to the eye lens fibers and is present in immunologically homologous form in many vertebrate species, has been identified. By use of anti-MP70 monoclonal antibodies for immunofluorescence microscopy and electron microscopy, this polypeptide was...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1985
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2113615/
https://www.ncbi.nlm.nih.gov/pubmed/3891760
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collection PubMed
description A 70,000-D membrane protein (MP70), which is restricted to the eye lens fibers and is present in immunologically homologous form in many vertebrate species, has been identified. By use of anti-MP70 monoclonal antibodies for immunofluorescence microscopy and electron microscopy, this polypeptide was localized in lens membrane junctional domains. Both immunofluorescence microscopy and SDS PAGE reveal an abundance of MP70 in the lens outer cortex that coincides with a high frequency of fiber gap junctions in the same region.
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spelling pubmed-21136152008-05-01 Identification of a 70,000-D protein in lens membrane junctional domains J Cell Biol Articles A 70,000-D membrane protein (MP70), which is restricted to the eye lens fibers and is present in immunologically homologous form in many vertebrate species, has been identified. By use of anti-MP70 monoclonal antibodies for immunofluorescence microscopy and electron microscopy, this polypeptide was localized in lens membrane junctional domains. Both immunofluorescence microscopy and SDS PAGE reveal an abundance of MP70 in the lens outer cortex that coincides with a high frequency of fiber gap junctions in the same region. The Rockefeller University Press 1985-07-01 /pmc/articles/PMC2113615/ /pubmed/3891760 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Identification of a 70,000-D protein in lens membrane junctional domains
title Identification of a 70,000-D protein in lens membrane junctional domains
title_full Identification of a 70,000-D protein in lens membrane junctional domains
title_fullStr Identification of a 70,000-D protein in lens membrane junctional domains
title_full_unstemmed Identification of a 70,000-D protein in lens membrane junctional domains
title_short Identification of a 70,000-D protein in lens membrane junctional domains
title_sort identification of a 70,000-d protein in lens membrane junctional domains
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2113615/
https://www.ncbi.nlm.nih.gov/pubmed/3891760

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