Cargando…

Biochemical and functional characterization of a novel neuron-glia adhesion molecule that is involved in neuronal migration

Adhesion molecule on glia (AMOG) is a novel neural cell adhesion molecule that mediates neuron-astrocyte interaction in vitro. In situ AMOG is expressed in the cerebellum by glial cells at the critical developmental stages of granule neuron migration. Granule neuron migration that is guided by surfa...

Descripción completa

Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1987
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2114497/
https://www.ncbi.nlm.nih.gov/pubmed/2438288
_version_ 1782140433723293696
collection PubMed
description Adhesion molecule on glia (AMOG) is a novel neural cell adhesion molecule that mediates neuron-astrocyte interaction in vitro. In situ AMOG is expressed in the cerebellum by glial cells at the critical developmental stages of granule neuron migration. Granule neuron migration that is guided by surface contacts between migrating neurons and astroglial processes is inhibited by monoclonal AMOG antibody, probably by disturbing neuron-glia adhesion. AMOG is an integral cell surface glycoprotein of 45-50-kD molecular weight with a carbohydrate content of at least 30%. It does not belong to the L2/HNK-1 family of neural cell adhesion molecules but expresses another carbohydrate epitope that is shared with the adhesion molecules L1 and myelin- associated glycoprotein, but is not present on N-CAM or J1.
format Text
id pubmed-2114497
institution National Center for Biotechnology Information
language English
publishDate 1987
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21144972008-05-01 Biochemical and functional characterization of a novel neuron-glia adhesion molecule that is involved in neuronal migration J Cell Biol Articles Adhesion molecule on glia (AMOG) is a novel neural cell adhesion molecule that mediates neuron-astrocyte interaction in vitro. In situ AMOG is expressed in the cerebellum by glial cells at the critical developmental stages of granule neuron migration. Granule neuron migration that is guided by surface contacts between migrating neurons and astroglial processes is inhibited by monoclonal AMOG antibody, probably by disturbing neuron-glia adhesion. AMOG is an integral cell surface glycoprotein of 45-50-kD molecular weight with a carbohydrate content of at least 30%. It does not belong to the L2/HNK-1 family of neural cell adhesion molecules but expresses another carbohydrate epitope that is shared with the adhesion molecules L1 and myelin- associated glycoprotein, but is not present on N-CAM or J1. The Rockefeller University Press 1987-06-01 /pmc/articles/PMC2114497/ /pubmed/2438288 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Biochemical and functional characterization of a novel neuron-glia adhesion molecule that is involved in neuronal migration
title Biochemical and functional characterization of a novel neuron-glia adhesion molecule that is involved in neuronal migration
title_full Biochemical and functional characterization of a novel neuron-glia adhesion molecule that is involved in neuronal migration
title_fullStr Biochemical and functional characterization of a novel neuron-glia adhesion molecule that is involved in neuronal migration
title_full_unstemmed Biochemical and functional characterization of a novel neuron-glia adhesion molecule that is involved in neuronal migration
title_short Biochemical and functional characterization of a novel neuron-glia adhesion molecule that is involved in neuronal migration
title_sort biochemical and functional characterization of a novel neuron-glia adhesion molecule that is involved in neuronal migration
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2114497/
https://www.ncbi.nlm.nih.gov/pubmed/2438288