The scanning model for translation: an update

The small (40S) subunit of eukaryotic ribosomes is believed to bind initially at the capped 5'-end of messenger RNA and then migrate, stopping at the first AUG codon in a favorable context for initiating translation. The first-AUG rule is not absolute, but there are rules for breaking the rule....

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1989
Materias:
Mini-Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2115416/
https://www.ncbi.nlm.nih.gov/pubmed/2645293
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description The small (40S) subunit of eukaryotic ribosomes is believed to bind initially at the capped 5'-end of messenger RNA and then migrate, stopping at the first AUG codon in a favorable context for initiating translation. The first-AUG rule is not absolute, but there are rules for breaking the rule. Some anomalous observations that seemed to contradict the scanning mechanism now appear to be artifacts. A few genuine anomalies remain unexplained.
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spelling pubmed-21154162008-05-01 The scanning model for translation: an update J Cell Biol Mini-Reviews The small (40S) subunit of eukaryotic ribosomes is believed to bind initially at the capped 5'-end of messenger RNA and then migrate, stopping at the first AUG codon in a favorable context for initiating translation. The first-AUG rule is not absolute, but there are rules for breaking the rule. Some anomalous observations that seemed to contradict the scanning mechanism now appear to be artifacts. A few genuine anomalies remain unexplained. The Rockefeller University Press 1989-02-01 /pmc/articles/PMC2115416/ /pubmed/2645293 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Mini-Reviews
The scanning model for translation: an update
title The scanning model for translation: an update
title_full The scanning model for translation: an update
title_fullStr The scanning model for translation: an update
title_full_unstemmed The scanning model for translation: an update
title_short The scanning model for translation: an update
title_sort scanning model for translation: an update
topic Mini-Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2115416/
https://www.ncbi.nlm.nih.gov/pubmed/2645293

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