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Unique distribution of the extracellular matrix component thrombospondin in the developing mouse embryo

Immunocytochemical localization of thrombospondin (TSP), a trimeric glycoprotein constituent of extracellular matrices, produced striking regional and temporal patterns of distribution in the developing mouse embryo. TSP was present in many basement membranes, surrounded epithelial cells, and was as...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1988
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2115645/
https://www.ncbi.nlm.nih.gov/pubmed/3204123
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description Immunocytochemical localization of thrombospondin (TSP), a trimeric glycoprotein constituent of extracellular matrices, produced striking regional and temporal patterns of distribution in the developing mouse embryo. TSP was present in many basement membranes, surrounded epithelial cells, and was associated with peripheral nerve outgrowth. During organogenesis, TSP was also found on the surface of myoblasts and chondroblasts, and TSP was differentially deposited in cortical layers. With differentiation of chondrocytes and myotubes immunoreactivity was decreased, and differential cortical staining was lost. Presence of TSP was associated with morphogenetic processes of proliferation, migration, and intercellular adhesion.
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spelling pubmed-21156452008-05-01 Unique distribution of the extracellular matrix component thrombospondin in the developing mouse embryo J Cell Biol Articles Immunocytochemical localization of thrombospondin (TSP), a trimeric glycoprotein constituent of extracellular matrices, produced striking regional and temporal patterns of distribution in the developing mouse embryo. TSP was present in many basement membranes, surrounded epithelial cells, and was associated with peripheral nerve outgrowth. During organogenesis, TSP was also found on the surface of myoblasts and chondroblasts, and TSP was differentially deposited in cortical layers. With differentiation of chondrocytes and myotubes immunoreactivity was decreased, and differential cortical staining was lost. Presence of TSP was associated with morphogenetic processes of proliferation, migration, and intercellular adhesion. The Rockefeller University Press 1988-12-01 /pmc/articles/PMC2115645/ /pubmed/3204123 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Unique distribution of the extracellular matrix component thrombospondin in the developing mouse embryo
title Unique distribution of the extracellular matrix component thrombospondin in the developing mouse embryo
title_full Unique distribution of the extracellular matrix component thrombospondin in the developing mouse embryo
title_fullStr Unique distribution of the extracellular matrix component thrombospondin in the developing mouse embryo
title_full_unstemmed Unique distribution of the extracellular matrix component thrombospondin in the developing mouse embryo
title_short Unique distribution of the extracellular matrix component thrombospondin in the developing mouse embryo
title_sort unique distribution of the extracellular matrix component thrombospondin in the developing mouse embryo
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2115645/
https://www.ncbi.nlm.nih.gov/pubmed/3204123