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THE IMMUNIZING POWER OF NUCLEOHISTON AND OF HISTON
The results obtained in the preceding experiments may be briefly summarized as follows: 1. Nucleohiston does not protect against a separate and subcutaneous injection of tetanus toxin, diphtheria toxin, hog-cholera bacillus, or anthrax bacillus. 2. Mixtures of nucleohiston and either tetanus toxin o...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1896
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2117929/ https://www.ncbi.nlm.nih.gov/pubmed/19866821 |
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author | Novy, F. O. |
author_facet | Novy, F. O. |
author_sort | Novy, F. O. |
collection | PubMed |
description | The results obtained in the preceding experiments may be briefly summarized as follows: 1. Nucleohiston does not protect against a separate and subcutaneous injection of tetanus toxin, diphtheria toxin, hog-cholera bacillus, or anthrax bacillus. 2. Mixtures of nucleohiston and either tetanus toxin or diphtheria toxin lose their specific toxic action—the latter much more rapidly than the former. Animals that recover after inoculation of such mixtures are not rendered immune. 3. In a mixture of nucleohiston and anthrax bacillus the latter is unaffected, even after the lapse of eleven days. 4. The destruction of specific toxins in a solution of nucleohiston, though in part due to sodium carbonate, is probably chiefly due to the nucleohiston. 5. Histon does not protect against a separate and subcutaneous injection of tetanus toxin, diphtheria toxin, hog-cholera bacillus, or anthrax bacillus. 6. In a mixture of histon and diphtheria toxin the latter is destroyed in a few minutes. This action is in part, if not wholly, due to the acidity of the histon solution. Similar mixtures of closely related bodies, serum globulin or albumoses, in Witte's pepton, give analogous results. The animals that recover from such inoculations are not rendered immune. Histon does not destroy the tetanus toxin as readily as the diphtheria toxin. 7. Histon possesses decided and marked toxic properties which are not due to the hydrochloric acid present. |
format | Text |
id | pubmed-2117929 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1896 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21179292008-04-18 THE IMMUNIZING POWER OF NUCLEOHISTON AND OF HISTON Novy, F. O. J Exp Med Article The results obtained in the preceding experiments may be briefly summarized as follows: 1. Nucleohiston does not protect against a separate and subcutaneous injection of tetanus toxin, diphtheria toxin, hog-cholera bacillus, or anthrax bacillus. 2. Mixtures of nucleohiston and either tetanus toxin or diphtheria toxin lose their specific toxic action—the latter much more rapidly than the former. Animals that recover after inoculation of such mixtures are not rendered immune. 3. In a mixture of nucleohiston and anthrax bacillus the latter is unaffected, even after the lapse of eleven days. 4. The destruction of specific toxins in a solution of nucleohiston, though in part due to sodium carbonate, is probably chiefly due to the nucleohiston. 5. Histon does not protect against a separate and subcutaneous injection of tetanus toxin, diphtheria toxin, hog-cholera bacillus, or anthrax bacillus. 6. In a mixture of histon and diphtheria toxin the latter is destroyed in a few minutes. This action is in part, if not wholly, due to the acidity of the histon solution. Similar mixtures of closely related bodies, serum globulin or albumoses, in Witte's pepton, give analogous results. The animals that recover from such inoculations are not rendered immune. Histon does not destroy the tetanus toxin as readily as the diphtheria toxin. 7. Histon possesses decided and marked toxic properties which are not due to the hydrochloric acid present. The Rockefeller University Press 1896-11-01 /pmc/articles/PMC2117929/ /pubmed/19866821 Text en Copyright © Copyright, 1896, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Novy, F. O. THE IMMUNIZING POWER OF NUCLEOHISTON AND OF HISTON |
title | THE IMMUNIZING POWER OF NUCLEOHISTON AND OF HISTON |
title_full | THE IMMUNIZING POWER OF NUCLEOHISTON AND OF HISTON |
title_fullStr | THE IMMUNIZING POWER OF NUCLEOHISTON AND OF HISTON |
title_full_unstemmed | THE IMMUNIZING POWER OF NUCLEOHISTON AND OF HISTON |
title_short | THE IMMUNIZING POWER OF NUCLEOHISTON AND OF HISTON |
title_sort | immunizing power of nucleohiston and of histon |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2117929/ https://www.ncbi.nlm.nih.gov/pubmed/19866821 |
work_keys_str_mv | AT novyfo theimmunizingpowerofnucleohistonandofhiston AT novyfo immunizingpowerofnucleohistonandofhiston |