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Activation of the Flt3 signal transduction cascade rescues and enhances type I interferon–producing and dendritic cell development

Flt3 ligand (Flt3L) is a nonredundant cytokine in type I interferon–producing cell (IPC) and dendritic cell (DC) development, and IPC and DC differentiation potential is confined to Flt3(+) hematopoietic progenitor cells. Here, we show that overexpression of human Flt3 in Flt3(−) (Flt3(−)Lin(−)IL-7R...

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Detalles Bibliográficos
Autores principales:	Onai, Nobuyuki, Obata-Onai, Aya, Tussiwand, Roxane, Lanzavecchia, Antonio, Manz, Markus G.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2006
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118073/ https://www.ncbi.nlm.nih.gov/pubmed/16418395 http://dx.doi.org/10.1084/jem.20051645

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